BBS1
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Official Full Name
Bardet-Biedl syndrome 1 (human) -
Overview
Bardet-Biedl syndrome 1 protein is a protein that in humans is encoded by the BBS1 gene. -
Synonyms
BBS1;Bardet-Biedl syndrome 1 (human);Bardet-Biedl syndrome 1;Bardet-Biedl syndrome 1 protein;BBS1_HUMAN;BBS2-like protein 2;Bardet-Biedl syndrome 1 homolog;AI451249;D19Ertd609e
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BBS1-104H | Recombinant Human BBS1 Protein | Wheat Germ | Human | GST | 1-463 a.a. |
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| BBS1-105H | Recombinant Human BBS1 Protein | Wheat Germ | Human | GST | 187-295 a.a. |
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| BBS1-5671Z | Recombinant Zebrafish BBS1 | Mammalian Cell | Zebrafish | His |
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| BBS1-8504HCL | Recombinant Human BBS1 293 Cell Lysate | HEK293 | Human | Non |
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| BBS1-01HFL | Recombinant Full Length Human BBS1 Protein, N-His-SUMO-tagged | E.coli | Human | N-His,SUMO | Full L. Full Length |
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| BBS1-1583HF | Recombinant Full Length Human BBS1 Protein | In Vitro Cell Free System | Human | GST | Full L. 1-593 a.a. |
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Involved Pathway
BBS1 involved in several pathways and played different roles in them. We selected most pathways BBS1 participated on our site, such as Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BBSome-mediated cargo-targeting to cilium | PROL1,MKKS,CCT4,LZTFL1,BBS9,TTC8,CCT2,TCP1,CCT8,RAB3IP |
| Cargo trafficking to the periciliary membrane | EXOC8,CCT2,CCT4,CCT8,CNGA5,ARL3,MKKS,ARF4,PKD1,EXOC5 |
| Assembly of the primary cilium | DYNC1I2,ATAT1,CEP78,KIF3CB,IQCB1,OST4,IFT-20,CSNK1E,CCT5,CEP63 |
| Organelle biogenesis and maintenance | TTC26,BBS7,MRPS24,IFT81,MRPS22,MTFMT,IFT88,MRPL28,UNC119.1,CNGA5 |
Protein Function
BBS1 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,patched binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS1 itself. We selected most functions BBS1 had, and list some proteins which have the same functions with BBS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| smoothened binding | PTCH1,PTCH2 |
| protein binding | FRAG1,BIRC7,KLK13,RC3H2,TMPRSS7,TTR,CTRC,MNAT1,DUSP23,TIMM50 |
| RNA polymerase II repressing transcription factor binding | CHD4,SIN3A,TTC8,MTA1,BBS7,TBP,RBPJ,PPARA,HDAC1,SP1 |
| patched binding | IHH,CAV1,Shh,SMO,CCNB1,SETD6,PTCH1,DHH |
Interacting Protein
BBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS1.
BBS9;BBS7;BBS5;BBS4
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References
- Seo, S; Mullins, RF; et al. Subretinal Gene Therapy of Mice With Bardet-Biedl Syndrome Type 1. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:6118-6132(2013).
- Rabinovich-Nikitin, I; Solomon, B; et al. Inhibition of Amyloid Precursor Protein Processing Leads to Downregulation of Apoptotic Genes in Alzheimer's Disease Animal Models. NEURODEGENERATIVE DISEASES 13:107-109(2014).
