BBC3

  • Official Full Name

    BCL2 binding component 3

  • Overview

    This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

  • Synonyms

    BBC3;BCL2 binding component 3;JFY1;PUMA;JFY-1;bcl-2-binding component 3;p53 up-regulated modulator of apoptosis

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Mammalian cells
  • His
  • His&T7
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • Flag

    Involved Pathway

    BBC3 involved in several pathways and played different roles in them. We selected most pathways BBC3 participated on our site, such as p signaling pathway,Hippo signaling pathway,Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Huntingtons disease NDUFAB1,COX8A,SOD2,POLR2B,COX5A,PLCB3,SLC25A5,NDUFB8,POLR2J2,DNAI2
    Hippo signaling pathway PPP2R2A,APC,CTNNA3,FZD7,TGFB3,PARD6B,FZD2,ID1,CTGF,LLGL1
    Measles IFNA16,Ifna11,CD46,cgr2b,PIK3R3,TLR2,TBK1,TLR7,IFNA5,IRF7
    p signaling pathway CCNG1,TP73,TRP53,SERPINB5,IGFBP3,MDM4,GADD45BA,CD82A,RCHY1,GADD45AB

    Protein Function

    BBC3 has several biochemical functions, for example, ATPase binding,glycoprotein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBC3 itself. We selected most functions BBC3 had, and list some proteins which have the same functions with BBC3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SNAP23,ALG13,UBA6,GAGE2D,GTF3C5,CD79B,pab1,PTPRD,GH1,CSNK1G1
    glycoprotein binding VIM,PLAT,ITGB2,DNAJC5,CANX,SERPINA1E,SDC1,FLNA,F7,LMAN2
    ATPase binding S100A1,SLN,FAM119A,TOR1AIP1,FXYD3,ATP1B2,NUFIP1,DNAJC10,ATP6V0A1B,ATP6V0A2

    Interacting Protein

    BBC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBC3.

    Resources

    References

    • Myers, M; Morgan, FH; et al. PUMA regulates germ cell loss and primordial follicle endowment in mice. REPRODUCTION 148:211-219(2014).
    • Ray, S; Zhao, YX; et al. Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. CELLULAR SIGNALLING 26:1445-1455(2014).

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