BANF1
-
Official Full Name
barrier to autointegration factor 1 -
Overview
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein. -
Synonyms
BANF1;barrier to autointegration factor 1;barrier-to-autointegration factor;BAF;breakpoint cluster region protein 1;NGPS;BCRP1;D14S1460;MGC111161
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BANF1 involved in several pathways and played different roles in them. We selected most pathways BANF1 participated on our site, such as 2-LTR circle formation,APOBEC3G mediated resistance to HIV-1 infection,Autointegration results in viral DNA circles, which may be useful for your reference. Also, other proteins which involved in the same pathway with BANF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| 2-LTR circle formation | HMGA1,PSIP1,gag |
| Early Phase of HIV Life Cycle | PPIA,CCR5,gag,PSIP1 |
| Autointegration results in viral DNA circles | HMGA1,PSIP1,gag |
| Disease | IPO5,SSRP1,TRAT1,HEYL,CPSF6,MMAA,AP2A1,OPN1MW,GPC5,GPC6 |
| APOBEC3G mediated resistance to HIV-1 infection | APOBEC3G,PSIP1,HMGA1,gag,PPIA |
| Clearance of Nuclear Envelope Membranes from Chromatin | VRK2,TMPO,VRK1,LEMD3 |
| Cell Cycle, Mitotic | SET,STAG2,RCC2,AURKB,HIST2H3C,ANKLE2,MIS12,TCTN2,CEP70,CENPJ |
| Cell cycle | PMF1,ANAPC7,CENPJ,WRAP53,MIS18BP1,GINS2,STAG2,MAPRE1A,CCNE2,ZBTB17 |
Protein Function
BANF1 has several biochemical functions, for example, DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BANF1 itself. We selected most functions BANF1 had, and list some proteins which have the same functions with BANF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RFX1A,MIER3,HOXC3A,IRF2A,NKX2-5,ZNF547,AIFM1,POLG,TAF1A,NFIX |
| protein binding | SCARF1,NUB1,RERE,SYK,CDIPT,KIAA1530,SPRY1,SCARA5,FAM158A,FGA |
Interacting Protein
BANF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BANF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BANF1.
xav939;HLA-B;EMD;CDK5RAP3;ssdna_dcdgm;AIM2;PTBP3;RPL10;ATP6V1A
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