BAMBI
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Official Full Name
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) -
Overview
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. -
Synonyms
BAMBI;BMP and activin membrane-bound inhibitor homolog (Xenopus laevis);BMP and activin membrane-bound inhibitor homolog;NMA;BAMBI_HUMAN;BMP and activin membrane bound inhibitor homolog;Non metastatic gene A protein;Non-metastatic gene A protein;Putative transmembrane protein NMA;OTTHUMP00000019384
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Wheat Germ
- HEK293
- Mammalian Cell
- E.coli
- Human Cell
- Mammalian cells
- In Vitro Cell Free System
- Rabbit
- GST
- His
- His&T7
- Fc
- Non
- His&Fc&Avi
Involved Pathway
BAMBI involved in several pathways and played different roles in them. We selected most pathways BAMBI participated on our site, such as Wnt signaling pathway,TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAMBI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | RHOA,WNT11B,PPP3CA,PRKCA,FOSL1A,WNT5A,TRP53,FZD1,WNT4,LEF1 |
| TGF-beta signaling pathway | ZFYVE9,MAPK3,ID2A,ACVR1L,INHBA,ACVR1C,SMAD5,IFNG,BMP2B,FSTA |
Protein Function
BAMBI has several biochemical functions, for example, frizzled binding,type II transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAMBI itself. We selected most functions BAMBI had, and list some proteins which have the same functions with BAMBI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type II transforming growth factor beta receptor binding | TGFB1A,TGFB3,TGFBR1,TGFB1,TGFBR3,ENG,TGFB2 |
| frizzled binding | WNT9B,WNT8A,DVL1,DVL1B,WNT1,WNT7AA,WNT4,CTHRC1,WNT10B,LRP6 |
Interacting Protein
BAMBI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAMBI here. Most of them are supplied by our site. Hope this information will be useful for your research of BAMBI.
DVL2;LRP6;FZD5;SEP15;SOX30
Resources
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References
- Jin, Y; Wan, Y; et al. Treg/IL-17 Ratio and Treg Differentiation in Patients with COPD. PLOS ONE 9:-(2014).
- Le Bras, GF; Loomans, HA; et al. Activin A balance regulates epithelial invasiveness and tumorigenesis. LABORATORY INVESTIGATION 94:1134-1146(2014).
