Anpep
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Official Full Name
alanyl (membrane) aminopeptidase -
Overview
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. -
Synonyms
APN;CD13;LAP1;P150;PEPN;GP150;ANPEP;minopeptidase N;AP-M;AP-N;hAPN;aminopeptidase M;OTTHUMP00000194690;alanyl aminopeptidase;microsomal aminopeptidase;myeloid plasma membrane glycoprotein CD13
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Pig
- E.coli
- HEK293
- Mammalian cells
- Human
- E.coli
- Wheat Germ
- Mammalian Cell
- Human Cell
- In Vitro Cell Free System
- HEK293T
- His
- Non
- His&T7
- His&SUMO
- GST
- Myc&DDK
- His&GST&Myc
- His&Myc
- His&Fc&Avi
- Flag
Involved Pathway
Anpep involved in several pathways and played different roles in them. We selected most pathways Anpep participated on our site, such as Glutathione metabolism,Metabolic pathways,Renin-angiotensin system, which may be useful for your reference. Also, other proteins which involved in the same pathway with Anpep were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | CD37,CD3G,IL1B,CD9,GP9,CD8B1,IL2RA,GM-CSF,IL9R,EPOR |
| Metabolic pathways | ALDH2,CYP4F14,CHIA.2,ATP6V0C,ITPK1A,ARG2,PCCA,DHRS4L2,PNP,PGAM2 |
| Renin-angiotensin system | REN2,AGTR1A,NLN,KLK2,ATP6AP2,REN,KLK1B5,KLK1B22,PRCP,Ren1 |
| Glutathione metabolism | GSTAL,GGT1A,GCLC,MGST2,GSTK1,GPX4,GPX4A,GSTA1,GSTM6,GSR |
Protein Function
Anpep has several biochemical functions, for example, aminopeptidase activity,metalloaminopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Anpep itself. We selected most functions Anpep had, and list some proteins which have the same functions with Anpep. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloaminopeptidase activity | Npepo,LNPEP,XPNPEP1,ANPEPA,LTA4H,METAP2B,ERAP2,TRHDE,RNPEPL1,ERAP1 |
| virus receptor activity | NCAM1,PVR,CLEC5A,PVRL2,GYPA,NPC1,DAG1,IDE,CLDN1,SCARB2 |
| peptide binding | CLTA,TRHDE,LNPEP,RNPEP,TPP1,Npepo,Ctsl,RPS6KB2,GNRHR,BDKRB1 |
| zinc ion binding | SIAH2,KPNB1,ERI2,TIMM9,PDZRN3,TRIM67,ZCWPW1,MYLIPA,RBM14A,RNF187 |
| aminopeptidase activity | CTSH,METAP2,METAP1,CTSL2,METAP1D,METAP2A,ENPEP,DPP9,BLMH,Ctsl |
| metallopeptidase activity | ADAMTS1,CLCA2,ADAM8A,C6AST3,LNPEP,ADAMTSL3,BMP1A,PAPPAB,Npepo,NAALADL1 |
| receptor activity | GRIA4A,MED12,VMN1R47,CADM3,CRLF1,NOTCH2,THRAP3,Pla2r1,CD86,CLEC4E |
Interacting Protein
Anpep has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Anpep here. Most of them are supplied by our site. Hope this information will be useful for your research of Anpep.
Cep76;pulB;pyrG;gltX;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;SFN
Resources
Research Area
Myeloid Lineage MarkersGranulocyte Markers
Myeloid Cell
Mesenchymal Stem Cell Markers
Epithelial Cell Markers and Intracellular Molecules
Metalloproteases and Regulators
Adipose-derived Stem Cell Markers
CD Antigen (Granulocyte Markers)
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
Monocyte Markers
Liver Cancer Stem Cell Markers
Mesodermal Lineage Markers
Related Services
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References
- Mehta, JL; Mercanti, F; et al. Gene and MicroRNA Transcriptional Signatures of Angiotensin II in Endothelial Cells. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 65:123-129(2015).
- Hakki, SS; Kayis, SA; et al. Comparison of Mesenchymal Stem Cells Isolated From Pulp and Periodontal Ligament. JOURNAL OF PERIODONTOLOGY 86:283-291(2015).
