Ache
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Official Full Name
acetylcholinesterase (Yt blood group) -
Overview
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. -
Synonyms
ACHE;acetylcholinesterase (Yt blood group);YT;ACEE;ARACHE;N-ACHE
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Bovine
- Rat
- Chicken
- Zebrafish
- E.coli
- HEK293
- E. coli
- Trichoplusia Ni Larval
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- Human Cell
- HEK293T
- Mamanlian cells
- In Vitro Cell Free System
- Human Erythrocyte
- His
- GST
- N-His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
Ache involved in several pathways and played different roles in them. We selected most pathways Ache participated on our site, such as Glycerophospholipid metabolism,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ache were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | PLA2G12A,AGPAT1,LPCAT1,PLA2G4C,GPCPD1,PTDSS2,CDIPT,PHYKPL,PNPLA7,CEPT1 |
| Cholinergic synapse | PRKCA,CHRM3,ITPR3,KCNJ14,CHRNA6,GNGT1,FYN,ITPR1,PLCB2,PIK3R5 |
Protein Function
Ache has several biochemical functions, for example, acetylcholine binding,acetylcholinesterase activity,beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ache itself. We selected most functions Ache had, and list some proteins which have the same functions with Ache. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine hydrolase activity | AADAC,CELA2A |
| cholinesterase activity | CELL,CEL.1,CHKA,BCHE |
| protein homodimerization activity | TBC1D22A,STUB1,CTSE,HOMER2,NAMPT,CCBL1,SLC6A4,CHUK,FLT3,G6PDX |
| acetylcholinesterase activity | BCHE |
| laminin binding | NID1,ADAM9,TINAGL1,AGRN,ITGB1,LYPD3,NCL,LGALS3,ITGA9,THBS1 |
| beta-amyloid binding | OLFM1,SORL1,APOA1,CST3,APOEA,NGFR,APBB3,FBXO2,APBB1,APBA2 |
| acetylcholine binding | CHRFAM7A,CHRNA7,CHRM3,CHRNA3,CHRNA4,CHRNB1,CHRNB2,CHRNB3 |
| collagen binding | TGFBI,SERPINH1B,MMP13,LUM,CHADL,SERPINH2,DDR1,TLL1,Pdgfa&Pdgfb,FN1 |
| protein self-association | SLC9A3R1,TRIM32,CCL5,ABCD3,DYRK1A,RYR2,RSAD2,EPB49,SLC2A1,CTSC |
Interacting Protein
Ache has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ache here. Most of them are supplied by our site. Hope this information will be useful for your research of Ache.
COLQ;ENO1;GNB2L1;acetylcholine;2-phospho-d-glyceric acid;3se1_denan;acetyl-beta-methyl-thiocholine;neostigmine;Eno1;ATF7;Gnb2l1
Resources
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References
- Carod-Artal, FJ; et al. Illness due the Ebola virus: epidemiology and clinical manifestations within the context of an international public health emergency. REVISTA DE NEUROLOGIA 60:267-277(2015).
- Verma, N; Bhardwaj, A; et al. Biosensor Technology for Pesticides-A review. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:3093-3119(2015).
