AWAT1
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Official Full Name
acyl-CoA wax alcohol acyltransferase 1 -
Overview
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. -
Synonyms
AWAT1;acyl-CoA wax alcohol acyltransferase 1;DGAT2L3, diacylglycerol O acyltransferase 2 like 3;AWAT1_HUMAN;DGA;DGA2;Diacyl glycerol acyltransferase 2;Diacylglycerol acyltransferase 2;Diacylglycerol O acyltransferase 2 like 3;Diacylglycerol O-acyltransferase 2-like protein 3;Long-chain-alcohol O-fatty-acyltransferase 1;diacyl-glycerol acyltransferase 2;diacylglycerol O-acyltransferase 2-like 3;DGAT2L3
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
AWAT1 involved in several pathways and played different roles in them. We selected most pathways AWAT1 participated on our site, such as Acyl chain remodeling of DAG and TAG,Arachidonic acid metabolism,Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AWAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP4F2,DPEP2,CYP2Y3,PTGS2B,ALOX12B,PTGESL,GPX5,DPEP1,CYP2N13,CYP4A10 |
| Metabolism | AFMID,DPYDA.1,TYMP,CYP2R1,DGUOK,TMEM195,NUDT16,ETFDH,ADA,DSEL |
| Phospholipid metabolism | PNPLA8,CPNE7,SACM1LB,PITPNB,CDS1,PHOSPHO1,PTPMT1,CPNE1,CHKA,FIG4 |
| Acyl chain remodeling of DAG and TAG | MGLL,AWAT2,DGAT1B |
| Metabolism of lipids and lipoproteins | PMVK,CHKA,PPARGC1B,Alb,MED16,ACOT11A,ARSK,CYP4T8,VAPB,SACM1LB |
| Glycerophospholipid biosynthesis | CHKB,SLC44A5B,GPAT2,CEPT1A,AGPAT2,CHKA,AGPAT1,PLBD1,AWAT2,PLD4 |
Protein Function
AWAT1 has several biochemical functions, for example, long-chain-alcohol O-fatty-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AWAT1 itself. We selected most functions AWAT1 had, and list some proteins which have the same functions with AWAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| long-chain-alcohol O-fatty-acyltransferase activity | AWAT2 |
Interacting Protein
AWAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AWAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AWAT1.
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References
- Rodriguez, GM; Tashiro, Y; et al. Expanding ester biosynthesis in Escherichia coli. NATURE CHEMICAL BIOLOGY 10:259-+(2014).
- Miklaszewska, M; Kawinski, A; et al. Detailed characterization of the substrate specificity of mouse wax synthase. ACTA BIOCHIMICA POLONICA 60:209-215(2013).
