ATP2C1

  • Official Full Name

    ATPase, Ca++ transporting, type 2C, member 1

  • Overview

    The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    ATP2C1;ATPase, Ca++ transporting, type 2C, member 1;BCPM, benign chronic pemphigus (Hailey Hailey disease);calcium-transporting ATPase type 2C member 1;ATP2C1A;KIAA1347;PMR1;secretory pathway Ca2+/Mn2+ ATPase 1;SPCA1;AW061228;D930003G21Rik;hSPCA1;OTTHUMP00000216069;OTTHUMP00000216071;OTTHUMP00000216072;OTTHUMP00000216073;OTTHUMP00000216074;1700121J11Rik;AT2C1_HUMAN;ATP dependent Ca(2+) pump PMR1;ATP-dependent Ca(2+) pump PMR1;ATPase 2C1;BCPM;Calcium transporting ATPase type 2C member 1;HHD;HUSSY 28;MGC58010;MGC93231;OTTHUMP00000216066;OTTHUMP00000216068;OTTHUMP00000216075;PMR1L;SPCA;HUSSY-28;OTTHUMP00000216067;OTTHUMP00000216070

Recombinant Proteins

  • Human
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATP2C1-10012H Recombinant Human ATP2C1, His-tagged E.coli Human His 320-654a.a.
ATP2C1-452R Recombinant Rhesus monkey ATP2C1 Protein, His-tagged Mammalian Cell Rhesus macaque His
ATP2C1-974H Recombinant Human ATP2C1 protein, GST-tagged Wheat Germ Human GST
ATP2C1-148HCL Recombinant Human ATP2C1 cell lysate Human Non
ATP2C1-0816H Recombinant Human ATP2C1 Protein (Met1-Pro70), N-GST tagged E.coli Human GST Met1-Pro70
ATP2C1-268H Recombinant Human ATP2C1 Protein, His-tagged E.coli Human His Met1-Pro70
ATP2C1-281R Recombinant Rhesus Macaque ATP2C1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ATP2C1-281R-B Recombinant Rhesus Macaque ATP2C1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    ATP2C1 involved in several pathways and played different roles in them. We selected most pathways ATP2C1 participated on our site, such as Ion channel transport,Ion transport by P-type ATPases,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transmembrane transport of small molecules FXYD6,SLCO4A1,SLC30A1A,SLC26A7,LCN9,GSDMA2,FLVCR1,SLC17A1,SGK2,AQP3B
    Ion channel transport BEST4,CCC2,SGK2,CLCN4-2,CLCNKA,BSND,CLCN4,CLCN7,ATP1A1A.5,CLCN5
    Ion transport by P-type ATPases ATP11C,ATP2B3A,CUTC,ATP7B,ATP1A1A.4,ATP1A1A.3,ATP1A1A.2,ATP2C2,FXYD6-FXYD2,ATP13A

    Protein Function

    ATP2C1 has several biochemical functions, for example, ATP binding,calcium ion binding,calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2C1 itself. We selected most functions ATP2C1 had, and list some proteins which have the same functions with ATP2C1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TTL,PDPK1A,TOR1,SMCHD1,IARS,CSNK1E,PAPSS2A,PRKCBA,CIT,CDK20
    manganese-transporting ATPase activity ATP2C2
    metal ion binding RXRBB,DOM3Z,DOHH,ZHX2,GNA12,IDI2,FYNB,SCRT1,CA4A,PRKCH
    calcium ion binding DCHS1,PCDH2G4,CALML3,CELSR1,PCDH2G29,SLC25A12,AIF1L,PPP3CA,CHP2,CAPSLA
    signal transducer activity TSPAN6,VMN1R50,GPR113,NPFFR1L2,ADRB3B,VMN1R47,GNG13,APLNRA,TAAR9,GNG11
    calcium-transporting ATPase activity ATP2A1,ATP2A3,ATP2B1A,ATP2B4,ATP2B3A,ATP2A2B,ATP2B1,ATP2C2,ATP2B2,ATP2A1L
    manganese ion binding XPNPEP3,PRIMPOL,GALNT2,PPEF1,MPPE1,MRE11A,SOD2,DCP2,PIM1,NUDT16

    Interacting Protein

    ATP2C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2C1.

    STIM1

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