ATP1B3
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Official Full Name
ATPase, Na+/K+ transporting, beta 3 polypeptide -
Overview
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. -
Synonyms
ATP1B3;ATPase, Na+/K+ transporting, beta 3 polypeptide;sodium/potassium-transporting ATPase subunit beta-3;CD298;FLJ29027;Na, K-ATPase beta-3 polypeptide;sodium/potassium-dependent ATPase beta-3 subunit;sodium/potassium-dependent ATPase subunit bet
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Rat
- Mus musculus
- Xenopus laevis
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Human Cells
- HEK293T
- Mammalian cells
- E.coli expression system
- His
- His&T7
- Non
- Fc
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ATP1B3 involved in several pathways and played different roles in them. We selected most pathways ATP1B3 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin secretion | KCNMB1,INS2,PLCB1,ATP1B4,CAMK2G,CREB3L1,SNAP25,PRKCB,CREB5,KCNN3 |
| Salivary secretion | ATP1A2,ITPR3,GUCY1B3,PRKG2,PLCB1,TRPV6,GUCY1A3,CAP18,CST2,PRKCB |
| Thyroid hormone synthesis | PRKACG,HSPA5,DUOX2,ATP1B4,ASGR1,FXYD2,GPX3,GSR,DUOXA2,GPX8 |
| Gastric acid secretion | MYLK4,SLC26A7,KCNJ15,SLC9A4,CALML5,CALM2,KCNJ2,CAMK2B,PLCB4,SST |
| Aldosterone-regulated sodium reabsorption | INS1,KRAS,KCNJ1,PIK3CG,ATP1A1,FXYD4,INS,PIK3CB,SGK1,SCNN1G |
| Adrenergic signaling in cardiomyocytes | PPP2R5EA,TNNC1A,FXYD2,RPS6KA5,ATF6B,CAMK2G1,GNAI2A,ATP1B2,CALM3A,Adcy4 |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B11,ATP2B1,DNM3,ESR1,KLK1B22,PRKACB,KL,PLCB4,PLCB1,KLK1 |
| Cardiac muscle contraction | CACNG2,COX7A2A,COX4I2,CACNG6,TPM2,MYL2B,SLC8A1,CACNB3,ATP1A2A,TNNC1B |
| Bile secretion | CA2,ATP1B4,SLC9A3,Adcy4,SCARB1,AQP8,SLC10A1,SLC22A7,FXYD2,CYP3A4 |
Protein Function
ATP1B3 has several biochemical functions, for example, ATPase activator activity,ATPase binding,sodium:potassium-exchanging ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B3 itself. We selected most functions ATP1B3 had, and list some proteins which have the same functions with ATP1B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activator activity | RAB4A,DNAJB1,ATP1B2,DNAJC10,TOR1AIP2,TOR1AIP1,DNAJC24,AHSA1L,AHSA2,ATP1B1 |
| contributes_to sodium:potassium-exchanging ATPase activity | ATP1A1,ATP1B1,ATP1B2,ATP1A2 |
| ATPase binding | PEX19,ATP6V0A4,DRD1A,FAM119A,CHMP4A,ANK1,ZNHIT6,BBC3,PGR,NOP58 |
| sodium:potassium-exchanging ATPase activity | ATP1A1B,ATP1A3A,ATP1A3,ATP1A3B,FXYD2,ATP1A4,ATP1A1A.1,ATP1A1,ATP1A2,ATP1A1A.5 |
Interacting Protein
ATP1B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B3.
PTP4A3;b3xyc5_sollc;cona_canen;1C;P
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