ATL1
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Official Full Name
atlastin GTPase 1 -
Overview
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
ATL1;atlastin GTPase 1;spastic paraplegia 3A (autosomal dominant) , SPG3, SPG3A;atlastin-1;AD FSP;atlastin;FSP1;Atlastin1;Brain specific GTP binding protein;GBP3;SPG 3A;SPG3;GBP-3;hGBP3;GTP-binding protein 3;guanylate-binding protein 3;spastic paraplegia 3 protein A;brain-specific GTP-binding protein;guanine nucleotide-binding protein 3;HSN1D;SPG3A;AD-FSP
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Zebrafish
- Rat
- Macaca fascicularis
- Mus musculus
- Pongo Abelii
- Bovine
- Arabidopsis thaliana
- Insect Cells
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293T
- HEK293
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ATL1 involved in several pathways and played different roles in them. We selected most pathways ATL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ATL1 has several biochemical functions, for example, GTP binding,GTPase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATL1 itself. We selected most functions ATL1 had, and list some proteins which have the same functions with ATL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | PRKD1,RCAN1,BNIPL,APAF1,OAT,POU3F2,HACL1,GRB2,PVRL2,RAF1 |
| GTPase activity | GNAI1,NKIRAS2,ARL8A,ARF1,TUBAL3,RAB4B,RAB9B,RAP1B,RIT2,DNM1L |
| GTP binding | RND1,TUBA8L,SEPT10,GIMAP4,EIF2S3,C9orf86,EEF1A1B,TUBB2B,GNA13,RND1L |
| protein binding | CIB3,SOST,CCDC22,HNRNPK,NR0B1,MAP2K7,CDK20,PTPRR,COA6,SMU1 |
Interacting Protein
ATL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATL1.
TMED2;Rtn3;Reep5;Rtn4;RTN4;TMED10;TMED9
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References
- Peng, Y; Bo, L; et al. Interaction between antigen presenting cells and autoreactive T cells derived from BXSB mice with murine lupus. CELL RESEARCH 17:556-564(2007).
- Han, SH; Li, B; et al. Isolation and functional analysis of autoreactive T cells from BXSB mice with murine lupus. JOURNAL OF AUTOIMMUNITY 19:45-54(2002).
