ATF3
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Official Full Name
activating transcription factor 3 -
Overview
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. -
Synonyms
ATF3;activating transcription factor 3;cyclic AMP-dependent transcription factor ATF-3;cAMP-dependent transcription factor ATF-3;FLJ41705
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- Sf9 Cells
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His&GST
- GST
- HIS
- His
- His&SUMO
- Non
- His&Fc&Avi
- SUMO&Trx&His
Involved Pathway
ATF3 involved in several pathways and played different roles in them. We selected most pathways ATF3 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | HLA-DRA,DVL1,CD40,VDAC1,WNT5B,HRAS,KAT2B,POLD1,HLA-DRB3,MYBL2 |
Protein Function
ATF3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF3 itself. We selected most functions ATF3 had, and list some proteins which have the same functions with ATF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | HNF1A,STAT3,ZNF821,TFEB,FOXI1,YY1,NR1H3,ZNF335,PRDM5,TCF7 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | RAX,SREBF2,TBP,FOXA2,PAX8,FOSL1A,CDX4,GLI2,ZKSCAN3,KLF13 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | NHLH1,CEBPA,FOXF2,GATA2B,GATA5,GATA3,IRF2,FOXC1,ALX4,GATA4 |
| protein homodimerization activity | PLEK,NUDT21,PTS,IZUMO1,BARD1,CALCOCO2,ENO2,PDK2,ERP29,VWF |
| transcription regulatory region sequence-specific DNA binding | ARNTL,BACH1B,HIF1AL,CREB3L3,POU5F1,FOXJ1,SUV39H1,NKX3,ARNTL1A,PER2 |
| identical protein binding | HSPB1,TP53,DHX8,DYNLT1,SMAD6,HACL1,NFKB1,SIRT1,SHMT2,AGXT2L1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | GATA3,ZFP90,HES1,TCF3,FOXO1,NKX6-1,GCFC2,TFAP2A,ZFP746,CC2D1B |
| protein heterodimerization activity | MID1,TAF9,GRIN2A,HIST1H2BA,GCLC,ITGB1,HIST1H2AF,IKBKG,DMRT3A,UGT1A4 |
| protein binding | SLBP,CLEC18A,SELENBP1,MASP1,ZDHHC13,SEC16B,UBQLN2,BNIP3L,ITGA6,CD1A |
Interacting Protein
ATF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF3.
JUN;FHL2;SH2D1A;HBZ;ATF2;FOSL2;JUNB;JUND;ATF7
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References
- Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).
- Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
