ASIC1
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Official Full Name
acid-sensing (proton-gated) ion channel 1 -
Synonyms
ASIC1;acid-sensing (proton-gated) ion channel 1;100;ENSG00000110881;ASIC;ACCN2;BNaC2;12q12;acid-sensing ion channel 1;acid-sensing ion channel 1;brain sodium channel 2;acid-sensing ion channel 1a protein;amiloride-sensitive cation channel 2, neuronal;Cation channel, amiloride-sensitive, neuronal, 2
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- Wheat Germ
- E.Coli or Yeast
- Insect Cell
- HEK293T
- Mamanlian cells
- In Vitro Cell Free System
- Myc&DDK
- GST
- His
- Non
- Flag
Involved Pathway
ASIC1 involved in several pathways and played different roles in them. We selected most pathways ASIC1 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory mediator regulation of TRP channels | BDKRB1,TRPV1,TRPM8,MAP2K6,CYP2C55,PPP1CB,PLCB3,IL1R1,PRKCE,PRKACB |
Protein Function
ASIC1 has several biochemical functions, for example, acid-sensing ion channel activity,ion gated channel activity,ligand-gated sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASIC1 itself. We selected most functions ASIC1 had, and list some proteins which have the same functions with ASIC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-gated sodium channel activity | ASIC1B,ASIC1A,ACCN3,ASIC3,SCNN1D,ASIC5,ACCN5,ASIC1C,ASIC4A,ASIC2 |
| protein binding | PLK3,TCHP,LCOR,NCLN,Il4ra,JPH2,DOT1L,RAB32,PLIN1,RPL13 |
| ion gated channel activity | ACCN2 |
| acid-sensing ion channel activity | ASIC1A,ACCN2,ASIC1B,ASIC1C |
Interacting Protein
ASIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASIC1.
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References
- Lin, LH; Jin, JW; et al. Acid-sensing ion channel 1 and nitric oxide synthase are in adjacent layers in the wall of rat and human cerebral arteries. JOURNAL OF CHEMICAL NEUROANATOMY 61-62:161-168(2014).
- Dymowska, AK; Schultz, AG; et al. Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 307:C255-C265(2014).
