ASCL2
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Official Full Name
achaete-scute complex homolog 2 (Drosophila) -
Overview
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. -
Synonyms
ASCL2;achaete-scute complex homolog 2 (Drosophila);achaete scute complex (Drosophila) homolog like 2 , achaete scute complex like 2 (Drosophila);achaete-scute homolog 2;ASH2;bHLHa45;HASH2;Achaete scute complex like 2;Achaete scute homolog 2;achaete-scute complex-like 2;ASCL2_HUMAN;ASH-2;Class A basic helix-loop-helix protein 45;Mash2;OTTHUMP00000011229;mammalian achaete/scute homologue 2
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Flag
- His&Myc
- His&Fc&Avi
Involved Pathway
ASCL2 involved in several pathways and played different roles in them. We selected most pathways ASCL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ASCL2 has several biochemical functions, for example, E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL2 itself. We selected most functions ASCL2 had, and list some proteins which have the same functions with ASCL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | DMRT3,HMGB1,TP73,SIM1,THRA,MZF1,YY1,HSF4,CEBPA,PITX2 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | BTG2,GCFC2,PITX2,ATF3,SNAI1,SP3,GFI1,BACH1,TCF3,SREBF2 |
| protein dimerization activity | STK4,MYCL1,EPAS1B,POLR2J2,NUP210,AHR,ARNTL,CLOCK,MESPAB,STK3 |
| E-box binding | GATA3,AHR,SREBF2,NEUROG1,NEUROD1,ATOH8,ARNTL,TFAP4,NEUROD2,TCF21 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX6-1,ETV2,ZBTB7A,H2AFZ,ZNF92,ETV1,PDX1,HHEX,RFX8,MYF6 |
Interacting Protein
ASCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL2.
Resources
Research Area
Notch FamilyCancer Stem Cell Transcription Factors
Epithelial Stem Cell Transcription Factors
Intestinal Stem Cell Markers
Related Services
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References
- Liu, XD; Chen, X; et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. NATURE 507:513-+(2014).
- Dessein, AF; Stechly, L; et al. Autocrine Induction of Invasive and Metastatic Phenotypes by the MIF-CXCR4 Axis in Drug-Resistant Human Colon Cancer Cells. CANCER RESEARCH 70:4644-4654(2010).
