ARPC4
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Official Full Name
actin related protein 2/3 complex, subunit 4 -
Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. -
Synonyms
ARPC4;actin related protein 2/3 complex, subunit 4;actin-related protein 2/3 complex subunit 4;Actin related protein 2/3 complex subunit 4;Actin related protein 2/3 complex subunit 4 20 kD;Actin related protein 2/3 complex subunit 4 20kDa;ARC20;Arp2/3 complex 20 kDa subunit;Arp2/3 protein complex subunit p20;ARPC 4;ARPC4_HUMAN;MGC13544;OTTHUMP00000165252;OTTHUMP00000207520;p20 Arc;p20-ARC;p20ARC;20kDa;AI327076;5330419I20Rik
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Human Cells
- GST
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARPC4-9885H | Recombinant Human ARPC4, GST-tagged | E.coli | Human | GST | 1-168a.a. | |
| ARPC4-11585Z | Recombinant Zebrafish ARPC4 | Mammalian Cell | Zebrafish | His |
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| ARPC4-300H | Recombinant Human ARPC4 Protein, His-tagged | E.coli | Human | His |
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| ARPC4-3088M | Recombinant Mouse ARPC4, His-tagged | E.coli | Mouse | His | 91 |
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| Arpc4-3106M | Recombinant Mouse Arpc4, His-tagged | E.Coli or Yeast | Mouse | His | 91 |
|
| ARPC4-4611C | Recombinant Chicken ARPC4 | Mammalian Cell | Chicken | His |
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| ARPC4-848H | Recombinant Human ARPC4 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARPC4-8684HCL | Recombinant Human ARPC4 293 Cell Lysate | HEK293 | Human | Non |
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| ARPC4-0532H | Recombinant Human ARPC4 Protein (Ala3-Leu165), N-His-tagged | E.coli | Human | His | Ala3-Leu165 |
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| ARPC4-1100HF | Recombinant Full Length Human ARPC4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 78 amino acids |
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| ARPC4-151H | Recombinant Human ARPC4 Protein, His-tagged | Human Cells | Human | His |
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| Arpc4-1694M | Recombinant Mouse Arpc4 protein, His-tagged | E.coli | Mouse | His | Ala79~Phe164 |
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| Arpc4-1695R | Recombinant Rat Arpc4 protein, His-tagged | E.coli | Rat | His | Ala3~Glu163 |
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Involved Pathway
ARPC4 involved in several pathways and played different roles in them. We selected most pathways ARPC4 participated on our site, such as Axon guidance,B Cell Receptor Signaling Pathway,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EPHB-mediated forward signaling | EPHB4B,KALRN,ITSN1,ARPC3,EFNB2,ACTR2,EPHB4A,ACTR2B,CFL1,ARHGEF28 |
| B Cell Receptor Signaling Pathway | IKBKB,CDK2,PIK3R3,LIME1,NEDD9,CD79B,MAP4K1,BCL10,PILRB,CD72 |
| Axon guidance | PPP3CC,EPHB4,ACTR2B,SEMA6C,PSPN,RGS3,CNTN1,COL9A1A,PLXNB2,TRPC4 |
| Endocytosis | GIT2A,FGFR2,WASLB,VPS37C,ARPC1B,WAS,DDL-2,ARFGAP3,CHMP3,FGFR3 |
| Developmental Biology | FGF10B,LGI2B,NR6A1,CACNG2,EFNA3,CDK8,EFNB3,SPTBN1,EFNB3B,ACTR3 |
| CDC42 signaling events | TNK2,CTNNA1,ARPC5,ACTR3,ARPC2,BAIAP2,ARPC3,ACTR2,CFL1,IQGAP3 |
| EPH-Ephrin signaling | SHB,ARPC2,EFNA4,EFNA3,EFNA2,CLTB,ACTR2,EPHB3A,EFNA1,KALRN |
| Bacterial invasion of epithelial cells | CLTA,RHOG,CTTN,PIK3CD,GAB1,PIK3R1,PIK3CG,RAC1,WASF2,RHOA |
Protein Function
ARPC4 has several biochemical functions, for example, contributes_to actin filament binding,enzyme binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC4 itself. We selected most functions ARPC4 had, and list some proteins which have the same functions with ARPC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | ATP6AP2,PPP1R3B,RCOR3,SLC18A1,PTEN,HIST1H2AN,PEX5,PLAUR,MAPK14,CASP2 |
| protein binding | PAPD4,OLFM1,PPP2R1B,TSR2,HDGFRP2,CSNK2A2,NRBP1,ZNF83,CDC42EP4,CDK5 |
| contributes_to actin filament binding | MYH10,ARPC5,ARPC1B,ARPC2,MYH9,ACTR2,ACTR3,ARPC3 |
| structural constituent of cytoskeleton | ACTG1,TUBA3C,TUBB2B,INA,MSN,TLN2A,ACTA1,TUBGCP4,TUBGCP2,YEATS4 |
Interacting Protein
ARPC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC4.
PNMA5;EIF1B;ACTR3B;malS;pepF1;RNF130;NELFCD;ARPC5L;ere_dna;FN1;VCAM1;FLNA;MYH9;WAS
Resources
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References
- Li, X; Li, JH; et al. ARP2/3 complex-mediated actin dynamics is required for hydrogen peroxide-induced stomatal closure in Arabidopsis. PLANT CELL AND ENVIRONMENT 37:1548-1560(2014).
- Petchampai, N; Sunyakumthorn, P; et al. Novel Identification of Dermacentor variabilis Arp2/3 Complex and Its Role in Rickettsial Infection of the Arthropod Vector. PLOS ONE 9:-(2014).
