ARHGEF18

  • Official Full Name

    Rho/Rac guanine nucleotide exchange factor (GEF) 18

  • Overview

    Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    ARHGEF18;Rho/Rac guanine nucleotide exchange factor (GEF) 18;rho guanine nucleotide exchange factor 18;KIAA0521;MGC15913;P114 RhoGEF;Rho specific guanine nucleotide exchange factor p114;SA-RhoGEF

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293
  • GST
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARHGEF18-9836H Recombinant Human ARHGEF18, GST-tagged E.coli Human GST 1-89a.a.
ARHGEF18-1893M Recombinant Mouse ARHGEF18 Protein Mammalian Cells Mouse His
ARHGEF18-783H Recombinant Human ARHGEF18 protein, GST-tagged Wheat Germ Human GST
ARHGEF18-1149HF Recombinant Full Length Human ARHGEF18 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 89 amino acids
ARHGEF18-1214H Recombinant Human ARHGEF18 Protein (159-551 aa), GST-tagged E.coli Human GST 159-551 aa
ARHGEF18-694M Recombinant Mouse ARHGEF18 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ARHGEF18-694M-B Recombinant Mouse ARHGEF18 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ARHGEF18 involved in several pathways and played different roles in them. We selected most pathways ARHGEF18 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by GPCR PYYA,GAL,NTS,TAS2R3,ARHGEF16,NMB,OR10A5,OXGR1,GPR39,OXTRL
    GPCR downstream signaling PENK,NPS,OR56A1,PTHLH,TRPC6A,ADRB3,CXCR6,CHRM5,TAS2R16,FPR-RS3
    G alpha (12/13) signalling events ARHGAP4,MCF2L,ARHGEF9,NET1,ADRA1B,ARHGEF16,FGD4,RHOB,FGD2,ARHGEF17
    NRAGE signals death through JNK ARHGAP4,FGD2,ARHGEF9,ARHGEF18A,OBSCN,DCLRE1B,ABR,AKAP13,ARHGEF16,ARHGEF17
    Rho GTPase cycle ARHGAP17A,RHOT1B,ARHGEF3,ARHGAP8,RHOUA,ARHGAP4,AKAP13,FGD4A,RHOV,DEPDC1B
    Regulation of RhoA activity ARHGEF10,ARHGEF25,FARP1,ECT2,ABR,ARAP1,MCF2L,DEF6,NET1,DLC1
    Signal Transduction ABHD12,PROK2,GPR177,CGNB,WNT8-2,TMED5,STARD13,EVC2,PYGO2,RBP4
    Cell death signalling via NRAGE, NRIF and NADE KALRN,OBSCN,FGD4,FGD4A,NET1,ARHGEF9,PLEKHG2,ABR,BCL2L11,TRIO

    Protein Function

    ARHGEF18 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF18 itself. We selected most functions ARHGEF18 had, and list some proteins which have the same functions with ARHGEF18. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity PLEKHG2,PLEKHG4,AKAP13,PREX1,ARHGEF10,FARP1,ARHGEF33,ITSN2,RASGRF2B,ARHGEF12
    guanyl-nucleotide exchange factor activity FGD3,ARHGEF7A,FFAR1,DENND1C,SH2D3C,KNDC1,TBC1D10A,RAPGEF1B,RASGRP3,VAV3B

    Interacting Protein

    ARHGEF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF18.

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