ARHGEF10
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 10 -
Overview
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. -
Synonyms
ARHGEF10;Rho guanine nucleotide exchange factor (GEF) 10;rho guanine nucleotide exchange factor 10;Gef10;KIAA0294;ARHGA_HUMAN;DKFZp686H0726;MGC131664
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF10-9832H | Recombinant Human ARHGEF10, GST-tagged | E.coli | Human | GST | 400-700a.a. | |
| ARHGEF10-778H | Recombinant Human ARHGEF10 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGEF10-779H | Recombinant Human ARHGEF10 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGEF10-116HCL | Recombinant Human ARHGEF10 cell lysate | Human | Non |
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| ARHGEF10-1144HF | Recombinant Full Length Human ARHGEF10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 380 amino acids |
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Involved Pathway
ARHGEF10 involved in several pathways and played different roles in them. We selected most pathways ARHGEF10 participated on our site, such as Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of RhoA activity | ARHGEF28,ARHGEF10L,ABR,ARHGAP9,MYO9B,DLC1,ARHGEF15,AKAP13,DEF6,ARAP1 |
Protein Function
ARHGEF10 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,kinesin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF10 itself. We selected most functions ARHGEF10 had, and list some proteins which have the same functions with ARHGEF10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinesin binding | KIF18B,CLSTN1,AP1AR,PIFO,PLEKHM2,DISC1,KIAA1279,KIFAP3,IFT88,JAKMIP1 |
| protein binding | CYP1A1,MATN1,INO80,IGF1R,RPA2,NSL1,CASP1,EFCAB11,RIBC1,CNST |
| Rho guanyl-nucleotide exchange factor activity | FGD5,ARHGEF9B,PLEKHG2,ARHGEF10L,ARHGEF40,VAV3B,KALRNB,FGD1,ARHGEF37,ALS2CL |
Interacting Protein
ARHGEF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF10.
KIF3B;WDR48
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References
- Huang, IH; Hsiao, CT; et al. GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. JOURNAL OF CELL SCIENCE 127:4186-4200(2014).
- Martin, E; Harel, S; et al. pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans. PLOS ONE 9:-(2014).
