ARHGAP35
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Official Full Name
Rho GTPase activating protein 35 -
Overview
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. -
Synonyms
glucocorticoid receptor DNA binding factor 1;Rho GAP p190A;ARHGAP35;Rho GTPase-activating protein 35;GRF-1;MGC10745;KIAA1722;P190-A;P190A;glucocorticoid receptor DNA-binding factor 1;p190ARhoGAP;GRF1;p190RhoGAP;Glucocorticoid receptor repression factor 1;GRLF1;Rho GTPase activating protein 35
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGAP35-26370TH | Recombinant Human ARHGAP35, His-tagged | E.coli | Human | His | 1055-1499 a.a. |
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| ARHGAP35-26370H | Recombinant Human ARHGAP35 Protein, N-His tagged | E.coli | Human | His |
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| ARHGAP35-5363H | Recombinant Human ARHGAP35 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGAP35-5578HF | Recombinant Full Length Human ARHGAP35 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 36 amino acids |
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Involved Pathway
ARHGAP35 involved in several pathways and played different roles in them. We selected most pathways ARHGAP35 participated on our site, such as Focal adhesion,Platelet activation,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP35 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | MYL5,PIK3CG,VAV1,CYBA,CLDN9,BCAR1,RAP1B,ITGAM,NCF1,CLDN10 |
| Regulation of Actin Cytoskeleton | ITGA7,MYLPF,SSH3,ACTN2,FGF6B,PIP4K2A,PIP5K1A,FN1A,Itga10&Itgb1,FGD |
| Platelet activation | ARHGEF12,PPP1CB,TLN1,GUCY1A3,PIK3CB,FGG,PIK3R1,PRKACA,GNAS,PIK3R3 |
| Focal adhesion | RAC3,PIK3R3,VASP,ERBB2,BIRC2,FLNA,MYL9A,FLT4,LAMC1,FN1A |
Protein Function
ARHGAP35 has several biochemical functions, for example, DNA binding,GTP binding,GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP35 itself. We selected most functions ARHGAP35 had, and list some proteins which have the same functions with ARHGAP35. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | TBC1D30,ARHGAP4,ADAP1,ARHGEF19,ARHGAP18,RGS11,TBC1D17,ARFGAP2,GIT2,TBC1D22B |
| transcription corepressor activity | ALX1,HDAC3,ANKRD1,MNT,KDM5B,SSX1,KCTD1,PAWR,HAND1,HSF4 |
| GTP binding | RND1L,GNAI1,ARL8B,TUBB4B,REM1,RABL2A,RAB34A,Arf2,INSR,RAB35 |
| DNA binding | FUS,H1M,MIER2,TTC5,ZNF800,EPAS1,OVOL2,ZNF133,E2F2,XRN1 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | MITF,CDX2,FOXD3,FOXO3,FERD3L,HMX1,ZC3H8,ETV6,NR2F6,E4F1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | CREB3L4,ETV3,NR1I3,EOMES,NHLH1,ZFY2,SP5,FOXF2,RELB,NKX2-1 |
Interacting Protein
ARHGAP35 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP35 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP35.
pi3p;BCL6
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References
- Bosch, DE; Siderovski, DP; et al. Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors. BIOCHEMISTRY 54:404-412(2015).
- Zhao, JM; Xu, H; et al. Rho GTPase-Activating Protein 35 rs1052667 Polymorphism and Osteosarcoma Risk and Prognosis. BIOMED RESEARCH INTERNATIONAL :-(2014).
