ARF3
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Official Full Name
ADP-ribosylation factor 3 -
Overview
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D.The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. -
Synonyms
ARF3;ADP-ribosylation factor 3;small GTP binding protein;ADP ribosylation factor 3;ARF3_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ARF3 involved in several pathways and played different roles in them. We selected most pathways ARF3 participated on our site, such as Endocytosis,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipid metabolism | SACM1LA,CHKB,FIG4,CEPT1,PITPNB,AWAT2,CPNE6,DGAT1B,ABHD3,PLD6 |
| Metabolism of lipids and lipoproteins | SLC27A5,G0S2,CSNK1G2,CPNE3,PIK3R6,SCP2B,MED6,ACSF3,SLCO1B1,CDK19 |
| Synthesis of PIPs at the Golgi membrane | FIG4,SACM1LA,SACM1L,SACM1LB,TPTE |
| Metabolism | IP6K3,SLC25A14,CYP3A7-CYP3AP1,COQ7,ACOT9.1,MED25,DECR1,OXSR1,TPMT.2,MED22 |
| Endocytosis | LDLR,ADRB1,SNX1,SPG20A,MET,CHMP4A,ARPC5LB,ERBB3B,RNF41,STAM |
| PI Metabolism | FIG4,SACM1LA,TPTE,SACM1LB,SACM1L,PITPNB |
Protein Function
ARF3 has several biochemical functions, for example, GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARF3 itself. We selected most functions ARF3 had, and list some proteins which have the same functions with ARF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | OPA1,RHOD,Arf2,RAP2C,GCH2,TUBA1L,GTPBP8,RAP1A,ANXA6,GMPPAA |
| GTPase activity | RAB8B,DDX3X,GNAI2,GNL1,RAB7,RRAGCA,RRAGCB,RRAGA,TRIM23,GTPBP10 |
Interacting Protein
ARF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARF3.
Kif1c;Bach1;Proser1;Bles03;ARFIP2;ATN1;MAPK13
ARF3 Related Signal Pathway
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References
- Nakazawa, Y; Hiraguri, A; et al. The dsRNA-binding protein DRB4 interacts with the Dicer-like protein DCL4 in vivo and functions in the trans-acting siRNA pathway. PLANT MOLECULAR BIOLOGY 63:777-785(2007).
- Padilla, PI; Pacheco-Rodriguez, G; et al. Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101:2752-2757(2004).
