APPL1

  • Official Full Name

    adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

  • Overview

    APPL1 (adaptor protein containing PH domain, PTB domain and leucine zipper motif 1) mediates adiponectin signaling in various types of cells. APPL1 is also thought to have a role in insulin signaling.

  • Synonyms

    APPL1;adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1;DCC-interacting protein 13-alpha;APPL;dip13-alpha;AKT2 interactor;signaling adaptor protein DIP13alpha;adapter protein containing PH domain, PTB domain an

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • GST
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
APPL1-9774H Recombinant Human APPL1, GST-tagged E.coli Human GST 1-323a.a.
APPL1-7563H Recombinant Human APPL1 Protein, His-tagged E.coli Human His Phe404~Ser673
APPL1-1001H Recombinant Human APPL1, His-tagged E.coli Human His
APPL1-1814M Recombinant Mouse APPL1 Protein Mammalian Cell Mouse His
APPL1-26345TH Recombinant Human APPL1, His-tagged E.coli Human His Full L. 1-709 a.a.
APPL1-6802Z Recombinant Zebrafish APPL1 Mammalian Cell Zebrafish His
APPL1-725H Recombinant Human APPL1 protein, GST-tagged Wheat Germ Human GST
APPL-724H Recombinant Human APPL protein, GST-tagged Wheat Germ Human GST
APPL1-8772HCL Recombinant Human APPL1 293 Cell Lysate HEK293 Human Non
APPL1-0140H Recombinant Human APPL1 Protein (Phe404-Ser673), His-tagged E.coli Human His Phe404-Ser673
APPL1-1194HF Recombinant Full Length Human APPL1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 709 amino acids
Appl1-1667M Recombinant Mouse Appl1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
APPL1-16H Recombinant Human APPL1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
APPL1-645M Recombinant Mouse APPL1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
APPL1-645M-B Recombinant Mouse APPL1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    APPL1 involved in several pathways and played different roles in them. We selected most pathways APPL1 participated on our site, such as Pathways in cancer,Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Colorectal cancer TCF7L2,BIRC5,RAC1,PIK3CD,MLH1,GSK3B,APC2,RAC2,RAF1,PIK3R1
    Pathways in cancer XIAP,CCDC6,AHA-1,FGF7,ETS1,MET,PGF,ARAF,TGFBR1,IL6

    Protein Function

    APPL1 has several biochemical functions, for example, identical protein binding,protein binding,protein kinase B binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPL1 itself. We selected most functions APPL1 had, and list some proteins which have the same functions with APPL1. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase B binding CCDC88A,BCL10,RARA,ANKRD2,CDC37,PDE3B,TRAF6,PINK1,BAD
    protein binding RPS6KB1,RNF175,SAMHD1,N6AMT1,SPATA13,GATAD2A,ATL2,RALGAPA1,EMX2,SUMO3
    identical protein binding HSPB8,PSME3,DAPK3,PAK2,PARK7,PFKM,UBE2G2,TLE1,ALCAMA,VWA2

    Interacting Protein

    APPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPL1.

    APPL2;RAB5A

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