APLP2
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Official Full Name
amyloid beta (A4) precursor-like protein 2 -
Overview
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimers disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
APLP2;amyloid beta (A4) precursor-like protein 2;amyloid-like protein 2;amyloid beta (A4) precursor like protein 2;Amyloid like protein 2;amyloid precursor protein homolog HSD2;Amyloid protein homolog;APLP-2;APLP2_HUMAN;APPH;APPL2;CDEBP;CDEI box binding protein;CDEI box-binding protein;amyloid precursor protein homolog HSD-2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Zebrafish
- Mus musculus
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- HEK293T
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APLP2-9746H | Recombinant Human APLP2, GST-tagged | E.coli | Human | GST | 33-360a.a. | |
| APLP2-395H | Recombinant Human APLP2 Protein, His-tagged | E.coli | Human | His | Met1~Gly210 | |
| APLP2-1462C | Recombinant Chicken APLP2 | Mammalian Cell | Chicken | His |
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| APLP2-1777M | Recombinant Mouse APLP2 Protein | Mammalian Cell | Mouse | His |
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| Aplp2-3444R | Recombinant Rat Aplp2, His-tagged | E.Coli or Yeast | Rat | His | 765 |
|
| APLP2-6619Z | Recombinant Zebrafish APLP2 | Mammalian Cell | Zebrafish | His |
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| APLP2-688H | Recombinant Human APLP2 protein, GST-tagged | Wheat Germ | Human | GST |
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| APLP2-92HCL | Recombinant Human APLP2 cell lysate | Human | Non |
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| APLP2-1110HF | Recombinant Full Length Human APLP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 522 amino acids |
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| APLP2-1938H | Recombinant Human APLP2 protein, His-tagged | HEK293 | Human | His | Gly 32 - Ser 692 |
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| APLP2-1939M | Recombinant Mouse APLP2 protein, His-tagged | HEK293 | Mouse | His | Gly 32 - Ser 636 |
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| APLP2-2283H | Recombinant Human APLP2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| APLP2-3275H | Recombinant Human APLP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| APLP2-624M | Recombinant Mouse APLP2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| APLP2-624M-B | Recombinant Mouse APLP2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Aplp2-630M | Recombinant Mouse Aplp2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RFL-25650MF | Recombinant Full Length Mouse Amyloid-Like Protein 2(Aplp2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (32-707) |
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| RFL-27372RF | Recombinant Full Length Rat Amyloid-Like Protein 2(Aplp2) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (32-765) |
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Involved Pathway
APLP2 involved in several pathways and played different roles in them. We selected most pathways APLP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APLP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
APLP2 has several biochemical functions, for example, DNA binding,heparin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APLP2 itself. We selected most functions APLP2 had, and list some proteins which have the same functions with APLP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transition metal ion binding | APLP1,APP,HRSP12,APPA,APPB |
| serine-type endopeptidase inhibitor activity | SERPINF2,WFDC3,SERPINB4,SPINLW1,SLPI,WFDC6,APPB,PTI,WFDC6B,SERPINA5 |
| identical protein binding | KIRRELA,SYT9,CASP6,PRPS2,IFI203,SMN2,ALS2CL,BRI3,GCC2,MLL1 |
| heparin binding | LIPH,NELL2,SERPINA10,SLIT1,APOH,SLIT1B,CYR61,MMP7,RPL22,CXCL13 |
| protein binding | ASB3,HMGCR,ZNF385C,SEC63,CCDC68,RWDD3,FHL3,HIST1H2BE,PDLIM5,HSPB11 |
| DNA binding | FOXB1B,POLR2A,FAM171B,ASCL1,ENG2B,HNRNPU,CSDC2A,ZFY2,ZFP521,POLR1C |
Interacting Protein
APLP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APLP2.
JUN;APP;APLP1;DEDD;MED12;ETS1;JUNB;NFKB1;Slc5a7
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References
- Peters, HL; Yan, Y; et al. APLP2 regulates the expression of MHC class I molecules on irradiated Ewing's sarcoma cells. ONCOIMMUNOLOGY 2:-(2013).
- Cheng, F; Cappai, R; et al. Amyloid Precursor Protein (APP)/APP-like Protein 2 (APLP2) Expression Is Required to Initiate Endosome-Nucleus-Autophagosome Trafficking of Glypican-1-derived Heparan Sulfate. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20871-20878(2014).
