APH1A

  • Official Full Name

    anterior pharynx defective 1 homolog A

  • Overview

    This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimers disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

  • Synonyms

    APH1A;anterior pharynx defective 1 homolog A (C. elegans);gamma-secretase subunit APH-1A;APH 1A;CGI 78;aph-1alpha;presenilin-stabilization factor;APH-1;APH-1A;CGI-78;6530402N02Rik
Cat.# Product name Source (Host) Species Tag Protein Length Price
APH1A-355R Recombinant Rhesus monkey APH1A Protein, His-tagged Mammalian Cell Rhesus macaque His
APH1A-184R Recombinant Rhesus Macaque APH1A Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
APH1A-184R-B Recombinant Rhesus Macaque APH1A Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
APH1A-2712H Recombinant Human APH1A Full Length Transmembrane protein (1-247 aa), His-SUMO-tagged In vitro E. coli expression system Human His&SUMO Full L. 1-247aa
APH1A-5685H Recombinant Human APH1A protein, His&Myc-tagged E.coli Human N-His&C-Myc 235-265aa
RFL14744MF Recombinant Full Length Mouse Gamma-Secretase Subunit Aph-1A(Aph1A) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-265)

    Involved Pathway

    APH1A involved in several pathways and played different roles in them. We selected most pathways APH1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APH1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    APH1A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by APH1A itself. We selected most functions APH1A had, and list some proteins which have the same functions with APH1A. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    APH1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APH1A here. Most of them are supplied by our site. Hope this information will be useful for your research of APH1A.

    APH1A Related Signal Pathway

    Resources

    Research Area

    Notch Pathway
    Notch Family
    Alzheimer's Disease
    E-Cadherin Ectodomain Shedding and Proteolytic Processing

    References

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