ALS2

  • Official Full Name

    amyotrophic lateral sclerosis 2 (juvenile)

  • Overview

    The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9;(VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of;GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein;localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in;this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.;Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    ALS2;amyotrophic lateral sclerosis 2 (juvenile);ALS2CR6, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6;alsin;amyotrophic lateral sclerosis 2 protein;amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 prot

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cell
  • E.Coli or Yeast
  • Wheat Germ
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ALS2-9600H Recombinant Human ALS2, His-tagged E.coli Human His N-term-304a.a.
ALS2-1577M Recombinant Mouse ALS2 Protein Mammalian Cell Mouse His
ALS2-166H Recombinant Human ALS2 Protein, His-tagged E.coli Human His
Als2-3402R Recombinant Rat Als2, His-tagged E.Coli or Yeast Rat His 1651
ALS2-497H Recombinant Human ALS2 Protein, GST-tagged Wheat Germ Human GST
ALS2-642R Recombinant Rat ALS2 Protein Mammalian Cell Rat His
ALS2-66HCL Recombinant Human ALS2 cell lysate Human Non
ALS2-298R Recombinant Rat ALS2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ALS2-298R-B Recombinant Rat ALS2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ALS2-491M Recombinant Mouse ALS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ALS2-491M-B Recombinant Mouse ALS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ALS2 involved in several pathways and played different roles in them. We selected most pathways ALS2 participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with ALS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyotrophic lateral sclerosis (ALS) TNF,NOS1,PPP3CA,GRIA2,PRPH,DAXX,MAPK13,CASP12,NEFM,BAD

    Protein Function

    ALS2 has several biochemical functions, for example, Rab GTPase binding,Rab guanyl-nucleotide exchange factor activity,Rac guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALS2 itself. We selected most functions ALS2 had, and list some proteins which have the same functions with ALS2. You can find most of the proteins on our site.

    Function Related Protein
    Rab guanyl-nucleotide exchange factor activity DCTD,DENND6B,FAM116A,RIN3,RABGEF1,DENND2A,FAM116B,DENND3,DENND5A,RGP1
    protein homodimerization activity ALX1,ADAM10,AOC3,NR0B1,PVRL1A,BARD1,RNF17,RAP1GAP,CAT,PLDN
    protein serine/threonine kinase activator activity MAP2K2,STRADA,MAP2K1,CALM2,IGF2,STK4,FAM20A,LTF,CDK5R1,CALM3
    Ran guanyl-nucleotide exchange factor activity SERGEF,RCC1,RCBTB2,RANBP10,RANGRF
    protein binding TNFSF12,ERGIC2,IL17RA,DCAF12L1,PTCRA,GP6,C2orf62,BAP1,RAB5C,PRDM13
    contributes_to guanyl-nucleotide exchange factor activity EIF2B1,HBXIP,C7orf59,EIF2B3,LAMTOR3,LAMTOR1,EIF2B4,LAMTOR2,EIF2B2,EIF2B5
    Rab GTPase binding SLC6A4,ZFYVE20,AP1G1,EHD1,NGFR,MYO5A,PIFO,RPH3A,RAB11FIP2,NDRG1
    Rac guanyl-nucleotide exchange factor activity VAV1,FARP1,ARHGEF4,PREX2,DOCK2,FARP2,ARHGEF2,VAV3,SPATA13

    Interacting Protein

    ALS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALS2.

    YWHAB;RAB5A;RAC1;CDC37;EEA1

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