ALG12
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Official Full Name
asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae) -
Overview
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the;eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor;(dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with;congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation.
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALG12-9572H | Recombinant Human ALG12, GST-tagged | E.coli | Human | GST | 375-488a.a. | |
| ALG12-3334C | Recombinant Chicken ALG12 | Mammalian Cell | Chicken | His |
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| ALG12-461H | Recombinant Human ALG12 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALG12-5710Z | Recombinant Zebrafish ALG12 | Mammalian Cell | Zebrafish | His |
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| ACVR1B-1532H | Recombinant Human ACVR1B protein, GST-tagged | E. coli | Human | N-GST | 211-448 aa |
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Involved Pathway
ALG12 involved in several pathways and played different roles in them. We selected most pathways ALG12 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CYP4A14,ISYNA1,NT5C3L,DHFRL1,ALG8,CYP11C1,SPHK1,LPIN3,NT5C1B-RDH14,PPAP2D |
| N-Glycan biosynthesis | MAN2A1,ST6GAL1,RABGNT1,ALG13,MAN1A1,ALG6,MGAT3,ALG14,ST6GAL2,MGAT2 |
Protein Function
ALG12 has several biochemical functions, for example, alpha-1,6-mannosyltransferase activity,dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity,mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG12 itself. We selected most functions ALG12 had, and list some proteins which have the same functions with ALG12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mannosyltransferase activity | ZNF408,GTDC2,POC1BL,B3GNT8,PIGV,POMT1,PIGZ,POMGNT2,DPY19L4,DPY19L3 |
| alpha-1,6-mannosyltransferase activity | DPY19L1,B3GNT9-PS,DPY19L4,B3GNT8,GALNTL4,UGGT1,GTDC2,POC1BL,PIGB,POMGNT2 |
Interacting Protein
ALG12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG12.
RPL13A;PRDX4
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