ALDH5A1
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Official Full Name
aldehyde dehydrogenase 5 family, member A1 -
Overview
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
ALDH5A1;aldehyde dehydrogenase 5 family, member A1;succinate-semialdehyde dehydrogenase, mitochondrial;SSADH;SSDH;succinate semialdehyde dehydrogenase;aldehyde dehydrogenase family 5 member A1;mitochondrial succinate semialdehyde dehydrogenase;NAD
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Yeast
- In Vitro Cell Free System
- His
- GST
- Non
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALDH5A1-26496TH | Recombinant Human ALDH5A1, His-tagged | E.coli | Human | His | 109-535 a.a. |
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| ALDH5A1-27041TH | Recombinant Human ALDH5A1, His-tagged | E.coli | Human | His | 488 amino acids |
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| ALDH5A1-2821H | Recombinant Human ALDH5A1, His-tagged | E.coli | Human | His |
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| ALDH5A1-450H | Recombinant Human ALDH5A1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALDH5A1-6188Z | Recombinant Zebrafish ALDH5A1 | Mammalian Cell | Zebrafish | His |
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| ALDH5A1-60HCL | Recombinant Human ALDH5A1 cell lysate | Human | Non |
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| ALDH5A1-1324H | Recombinant Human ALDH5A1 Protein (48-535 aa), His-tagged | Yeast | Human | His | 48-535 aa |
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| ALDH5A1-1412HF | Recombinant Full Length Human ALDH5A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 535 amino acids |
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| ALDH5A1-2508H | Recombinant Human ALDH5A1 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 48-535aa |
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Involved Pathway
ALDH5A1 involved in several pathways and played different roles in them. We selected most pathways ALDH5A1 participated on our site, such as Alanine, aspartate and glutamate metabolism,Butanoate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Butanoate metabolism | ACSM2B,ACSM5,BDH1,L2HGDH,ACSM3,HADHA,EHHADH,HMGCL,ACAT2,HMGCS1 |
| Alanine, aspartate and glutamate metabolism | ybaS,GPT,ABAT,ADSS,GPT2L,GFPT2,IL4I1,GFPT1,RIMKLB,GLUD1 |
| Metabolic pathways | PLD1A,MTMR3,CHIA,PIK3C2B,ALDH9A1,UGP2A,TALDO1,AGXT2,HYAL2,ST6GAL2 |
Protein Function
ALDH5A1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity,protein homodimerization activity,succinate-semialdehyde dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH5A1 itself. We selected most functions ALDH5A1 had, and list some proteins which have the same functions with ALDH5A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TCF3B,MAP3K5,PEX7,PTS,CIDEA,SQSTM1,PAH,CEBPE,SYT6,MGST1 |
| aldehyde dehydrogenase (NAD) activity | ALDH9A1A.1,ALDH9A1B,Aldh1a7,ALDH3A2,ALDH1L2,ALDH8A1,ALDH6A1,ALDH1A3,ALDH3A2B,ALDH9A1 |
Interacting Protein
ALDH5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH5A1.
NR3C1
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References
- Zuo, QS; Li, D; et al. Study on the Regulatory Mechanism of the Lipid Metabolism Pathways during Chicken Male Germ Cell Differentiation Based on RNA-Seq. PLOS ONE 10:-(2015).
- Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).
