AKAP8
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Official Full Name
A kinase (PRKA) anchor protein 8 -
Overview
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. -
Synonyms
AKAP8;A kinase (PRKA) anchor protein 8;A-kinase anchor protein 8;A kinase anchor protein;95kDa;AKAP95;DKFZp586B1222;A-kinase anchor protein, 95kDa;AKAP-8;AKAP 95;AKAP-95
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AKAP8-3032H | Recombinant Human AKAP8, His-tagged | E.Coli or Yeast | Human | His | 692 |
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| AKAP8-403H | Recombinant Human AKAP8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AKAP8-46HCL | Recombinant Human AKAP8 cell lysate | Human | Non |
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| ACP1-5711H | Recombinant Human ACP1 protein, His-tagged | E. coli | Human | N-His | 15-102 aa |
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| AKAP8-1354HF | Recombinant Full Length Human AKAP8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 692 amino acids |
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| AKAP8-633H | Recombinant Human AKAP8 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-210a.a. |
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Involved Pathway
AKAP8 involved in several pathways and played different roles in them. We selected most pathways AKAP8 participated on our site, such as G Protein Signaling Pathways,TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G Protein Signaling Pathways | GNG13B,ARHGEF1A,AKAP1B,GNGT2A,AKAP12B,AKAP1,AKAP5,AKAP4,GNA13,AKAP10 |
| TNF-alpha/NF-kB Signaling Pathway | KIAA1967,COMMD1,SMARCC2,SMARCB1,SMARCE1,PAPOLA,TNIP1,CAPN3,CRADD,RNF216 |
Protein Function
AKAP8 has several biochemical functions, for example, double-stranded DNA binding,poly(A) RNA binding,protein kinase A regulatory subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP8 itself. We selected most functions AKAP8 had, and list some proteins which have the same functions with AKAP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | PSMD4,FRG1,PEF1,PDIA4,RPS26,RPP30,PTBP1,NOP2,DDX10,MEX3C |
| zinc ion binding | TAB3,ADH4,MKRN3,GM3258,CAR5A,ADAM22,CPB1,RNF130,ZCCHC12,ADAM7 |
| double-stranded DNA binding | TEF,SETMAR,FEN1,XRCC5,TDG,RAD51B,RBMS1,RAD51C,TARDBP,HMGB3 |
| protein kinase A regulatory subunit binding | AKAP7,KCNQ1,AKAP6,RYR2,C2orf88,AKAP1,AKAP5,ARFGEF1,AKAP9,PRKACA |
Interacting Protein
AKAP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP8.
MYC;ESR1;CSNK2A1;Aurkb;Mis12;SCHIP1;ssrna_ug;E2F3;HNRNPA1;MATR3;YBX1;ILK;LRRK2;HIPK4;ESR2;HDAC11
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