AGL
-
Official Full Name
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -
Overview
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. -
Synonyms
AGL;amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase;amylo 1, 6 glucosidase, 4 alpha glucanotransferase;glycogen debranching enzyme;glycogen storage disease type III;9430004C13Rik;9630046L06Rik;AI850929;C77197;1110061O17Rik;Amylo 1 6 glucosidase 4 alpha glucanotransferase;GDE;Glycogen debrancher;amylo-1, 6-glucosidase, 4-alpha-glucanotransferase
Recombinant Proteins
- Human
- Mouse
- HEK293
- E.coli
- E. coli
- HEK293T
- Mammalian cells
- Myc&DDK
- His&T7
- Non
- N-GST
- N-His
- His
- His&Fc&Avi
- GST
- Flag
Involved Pathway
AGL involved in several pathways and played different roles in them. We selected most pathways AGL participated on our site, such as Glucose metabolism,Glycogen Metabolism,Glycogen breakdown (glycogenolysis), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GALNT9,SMPD5,MAN1C1,SGMS2,COQ2,GLCEA,mt-Atp8,FPGS,B4GALT7,GALNTL6 |
| Metabolism | GRX2,SLC5A9,CYP2AD2,SLCO1B1,PTGR1,MED29,B4GALT7,SLC25A32A,G0S2,FABP11A |
| Glycogen breakdown (glycogenolysis) | GYG2,GYG1,PYGMB,GYG1A,GYG1B |
| Glucose metabolism | SLC25A11,SLC25A10,EPM2A,PFKLB,GYG1A,SLC25A1A,SLC25A12,GYG1,SLC25A1,GYG1B |
| Starch and sucrose metabolism | TREH,UGT2A3,UGT1A6A,GYS1,G6PC3,ENPP3,PYGB,UGP2,AMY1B,GPIB |
| Glycogen Metabolism | GYG2,GYG1,GSK3AB |
| Metabolism of carbohydrates | CHST14,ST3GAL3A,SLC25A13,SLC5A2,SLC25A1,B3GNT2,EPM2A,OMD,HS3ST4,SLC5A4 |
Protein Function
AGL has several biochemical functions, for example, 4-alpha-glucanotransferase activity,amylo-alpha-1,6-glucosidase activity,glycogen debranching enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGL itself. We selected most functions AGL had, and list some proteins which have the same functions with AGL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4-alpha-glucanotransferase activity | AGLA |
| protein binding | IFT20,UBE2F,EXOC1,TSSK1,EXOSC3,KLC1,FLOT1,Ccl27a,MMP20,TBRG4 |
| polysaccharide binding | VTN,TINAG,PRG4,MBL1,VTNB,ENPP2,VTNA,CLEC18C,TINAGL1,CD209B |
| amylo-alpha-1,6-glucosidase activity | AGLA |
| polyubiquitin binding | FAM175B,FAM175A,VCP,DNAJB2,UBQLN1,RAD23A,ZFAND6,EPS15,DZIP3,PSMD4A |
Interacting Protein
AGL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGL here. Most of them are supplied by our site. Hope this information will be useful for your research of AGL.
PRKAB2;PRKAA2;RASSF5;APPL1;GABARAPL2;CBX1;SMAD3;Ppp1r3b;GABARAPL1;UVRAG;SH3GLB1
Resources
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References
- Julithe, R; Abou-Jaoude, G; et al. Modification of the Hepatitis B Virus Envelope Protein Glycosylation Pattern Interferes with Secretion of Viral Particles, Infectivity, and Susceptibility to Neutralizing Antibodies. JOURNAL OF VIROLOGY 88:9049-9059(2014).
- Zhu, L; Shen, WY; et al. Anti-Retinal Antibodies in Patients With Macular Telangiectasia Type 2. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:5675-5683(2013).
