ADSL
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Official Full Name
adenylosuccinate lyase -
Overview
Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADSL;adenylosuccinate lyase;Adenylosuccinase;AMPS;ASase;ASL;OTTHUMP00000199172;OTTHUMP00000199173;PUR8_HUMAN
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Human
- E.Coli or Yeast
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ADSL involved in several pathways and played different roles in them. We selected most pathways ADSL participated on our site, such as Alanine, aspartate and glutamate metabolism,Biosynthesis of antibiotics,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADSL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ADSS,ybaS,CAD,PPAT,GFPT2,ASPA,GLUD1,ASS1,GLUD1A,GLUD2 |
| Nucleotide Metabolism | ADSS,MTHFD2,OAZ1 |
| Metabolic pathways | ACSM3,NDUFS1,NMNAT2,BDH1,ALG6,SPS2,POLR2G,AGK,SLC27A5,SAT1A.1 |
| Purine ribonucleoside monophosphate biosynthesis | ADSS,PAICS,ADSSL1 |
| Metabolism of nucleotides | ADSS,ITPA,NUDT1,ADSSL1,NUDT15,DGUOK,ADAL,DCK,UPP2,DHODH |
| Biosynthesis of antibiotics | DAO,ECHS1,AKR1A1,GLYCTK,AGXT,CS,AMDHD2,CTH,PAICS,AK7 |
| Metabolism | SLC27A2A,KCNG4,CYP4F11,CRYM,BSG,FABP12,SCO1,INSIG2,BCKDK,AZIN1B |
| Purine metabolism | NUDT2,Adcy4,POLD1,PDE9A,NT5C1AA,POLD2,POLR1E,ENPP4,PDE4C,CANT1B |
Protein Function
ADSL has several biochemical functions, for example, (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity,N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity,NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADSL itself. We selected most functions ADSL had, and list some proteins which have the same functions with ADSL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
ADSL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADSL here. Most of them are supplied by our site. Hope this information will be useful for your research of ADSL.
USP4;DDA1;USP15;NOV
Resources
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References
- Yuan, TA; Gu, JR; et al. Molecular cloning, characterization and expression analysis of adenylosuccinate lyase gene in grass carp (Ctenopharyngodon idella). MOLECULAR BIOLOGY REPORTS 38:2059-2065(2011).
- Timmerman, P; Van Dijk, E; et al. Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-beta (FSH-beta) using domain Scan (TM) and Matrix Scan (TM) technology. MOLECULAR DIVERSITY 8:61-77(2004).
