ADRA2C
-
Official Full Name
adrenergic, alpha-2C-, receptor -
Overview
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. -
Synonyms
ADRA2C;adrenergic, alpha-2C-, receptor;ADRA2L2, ADRA2RL2;alpha-2C adrenergic receptor;ADRARL2;alpha-2CAR;alpha2-AR-C4;alpha-2C adrenoceptor;alpha-2C adrenoreceptor;alpha-2C-adrenergic receptor;alpha-2 adrenergic receptor subtype C4;ADRA2L2;ADR
Recombinant Proteins
- Zebrafish
- Mouse
- Rat
- Human
- Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
- zebrafish
- Guinea pig
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
ADRA2C involved in several pathways and played different roles in them. We selected most pathways ADRA2C participated on our site, such as Adrenaline signalling through Alpha-2 adrenergic receptor,Adrenaline,noradrenaline inhibits insulin secretion,Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | CXCL11.8,EDNRAB,RGR,PROKR1,CX3CR1,PMCH,APLNR,ADORA2B,EDN1,PYY |
| Amine ligand-binding receptors | ADRA1D,HRH3,ADRB2,ADRA1B,CHRM1,CHRM4,ADRa1A,ADRA2B,DRD1,ADRB3 |
| G alpha (z) signalling events | RGS4,ADRA2B,ADRA2A,RGS17,RGS20,RGS19 |
| Adrenaline,noradrenaline inhibits insulin secretion | GNB5A,ADRA2A,GNB5B,ADCY6,GNB3A,GNB3B,GNB5 |
| Adrenaline signalling through Alpha-2 adrenergic receptor | ADRA2B,ADRA2A |
| GPCR downstream signaling | SSTR4,EDNRB,OXGR1,DRD4,RHOC,ARHGEF17,CHRM2,PNOC,SOUL3,PPY |
| G alpha (i) signalling events | ADORA1,CXCR7B,SOUL4,CCR1,FPR-RS4,GPR18,OXGR1A.3,OPN5,OPN1MW,PYY |
| Adrenoceptors | ADRA2A,ADRa1A,ADRA1D,ADRA1B,ADRA2B,ADRB2,ADRB1,ADRB3 |
Protein Function
ADRA2C has several biochemical functions, for example, alpha-2A adrenergic receptor binding,alpha2-adrenergic receptor activity,epinephrine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA2C itself. We selected most functions ADRA2C had, and list some proteins which have the same functions with ADRA2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-2A adrenergic receptor binding | APLP1,UCHL1,ADRBK1,ADRB1 |
| epinephrine binding | ADRB2A,ADRB3A,ADRA2A,ADRB3B,ADRB3,ADRB2B,ADRB2,ADRA2B,ADRB1 |
| protein binding | NCKAP1L,SWSAP1,ADAMTSL3,GINS4,PDCD2,NR1H4,FBXO27,UBA52,TIMM50,ZNF410 |
| alpha2-adrenergic receptor activity | ADRA2B,ADRA2DA,ADRA2DB,ADRA2A |
| protein homodimerization activity | SLC14A2,OLIG2,SMAGP,CADM2A,IKZF4,CEBPE,GRM6,C16orf89,TIMELESS,IZUMO1 |
| protein heterodimerization activity | GABRR1,BCL2L2,P4HB,PRPH,BMP2B,HIST1H2BO,Pdgfa&Pdgfb,BCL2A,IKZF2,TGFB3 |
Interacting Protein
ADRA2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA2C here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA2C.
Resources
Related Services
Related Products
References
- Vazquez, S; Mladovan, AG; et al. Human breast cell lines exhibit functional alpha(2)-adrenoceptors. CANCER CHEMOTHERAPY AND PHARMACOLOGY 58:50-61(2006).
- Millan, MJ; La Cour, CM; et al. S33138[N-[4-[2-[(3aS, 9bR)-8-cyano-1,3a, 4,9b-tetrahydro[1]-benzopyrano[3,4-c] pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D-3 versus D-2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 324:587-599(2008).
