ADRA1B
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Official Full Name
adrenergic, alpha-1B-, receptor -
Overview
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. -
Synonyms
ADRA1B;adrenergic, alpha-1B-, receptor;alpha-1B adrenergic receptor;alpha-1B adrenoceptor;alpha-1B adrenoreceptor;alpha-1B-adrenergic receptor;ADRA1;ALPHA1BAR
Recombinant Proteins
- Rat
- Human
- Dog
- Mus musculus
- Mesocricetus auratus
- E.Coli or Yeast
- E. coli
- E.coli expression system
- His
- N-His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Adra1b-3316R | Recombinant Rat Adra1b, His-tagged | E.Coli or Yeast | Rat | His | 515 |
|
| ABCC4-2453H | Recombinant Human ABCC4 protein, His-tagged | E. coli | Human | N-His | 347-707 aa |
|
| RFL-23783CF | Recombinant Full Length Dog Alpha-1B Adrenergic Receptor(Adra1B) Protein, His-Tagged | E.coli expression system | Dog | His | Full L. Full Length (1-417) |
|
| RFL-25452MF | Recombinant Full Length Mouse Alpha-1B Adrenergic Receptor(Adra1B) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-514) |
|
| RFL-25833MF | Recombinant Full Length Mesocricetus Auratus Alpha-1B Adrenergic Receptor(Adra1B) Protein, His-Tagged | E.coli expression system | Mesocricetus auratus | His | Full L. Full Length (1-515) |
|
| RFL-524HF | Recombinant Full Length Human Alpha-1B Adrenergic Receptor(Adra1B) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-520) |
|
| RFL-9343RF | Recombinant Full Length Rat Alpha-1B Adrenergic Receptor(Adra1B) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-515) |
|
Involved Pathway
ADRA1B involved in several pathways and played different roles in them. We selected most pathways ADRA1B participated on our site, such as AMPK signaling,Adrenergic signaling in cardiomyocytes,Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium Regulation in the Cardiac Cell | CASQ2,RGS5B,CHRM1,GJA3,KCNJ5,GNB5B,GJA5,CASQ1,KCNJ3,GJA10 |
| G alpha (12/13) signalling events | KALRNB,RHOAE,GNA13,ARHGEF18,MCF2L,ECT2,FGD2,FGD4,ARHGEF9,FGD4A |
| AMPK signaling | CAMKK2,INS-IGF2,EIF4EBP1,SLC2A4RG,EEF2,PPARGC1B,CPT1B,ADRa1A,CPT1C,CPT1A |
| Calcium signaling pathway | ATP2A1L,CD38,AGTR1,ATP2B3B,ATP2B1A,EDNRBA,GRIN1B,PRKACAA,SLC25A5,ADORA2A |
| Adrenergic signaling in cardiomyocytes | PIK3CA,ATP1B4,CALM3,CACNG7,SCN1BB,GNAI2A,PRKACA,PIK3CG,AKT3A,PPP2R2CA |
| Class A/1 (Rhodopsin-like receptors) | HCAR1-2,CCR7,CCR6,PTGDR2,GPR37B,GPR132,NPFF,OPN5,PROK1,LPAR2A |
| Amine ligand-binding receptors | DRD1,ADRA2C,HRH3,TAAR1,CHRM1,ADRB3,CHRM2,ADRB1,CHRM3,ADRA2A |
| Adrenoceptors | ADRa1A,ADRA1D,ADRA2B,ADRB1,ADRA2A,ADRB2,ADRA2C,ADRB3 |
Protein Function
ADRA1B has several biochemical functions, for example, alpha1-adrenergic receptor activity,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA1B itself. We selected most functions ADRA1B had, and list some proteins which have the same functions with ADRA1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | KCNB2,LIMK2,TAP1,GRIN2A,DLG4B,CEBPE,F11R.1,ITGB1,TCF3A,HIST1H3C |
| alpha1-adrenergic receptor activity | ADRA1D,ADRA1BB,ADRa1A |
Interacting Protein
ADRA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA1B.
PPP1R9B;FLNC;IGHG1;ALB
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References
- Kordasz, ML; Manicam, C; et al. Role of alpha(1)-Adrenoceptor Subtypes in Pupil Dilation Studied With Gene-Targeted Mice. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:8295-8301(2014).
- Ichishima, K; Yamamoto, S; et al. alpha(1)-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes. BRITISH JOURNAL OF PHARMACOLOGY 161:193-206(2010).
