ADNP
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Official Full Name
activity-dependent neuroprotector homeobox -
Overview
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. -
Synonyms
ADNP;activity-dependent neuroprotector homeobox;activity dependent neuroprotector;activity-dependent neuroprotector homeobox protein;ADNP homeobox 1;ADNP1;KIAA0784;Activity dependent neuroprotective protein;OTTHUMP00000031275;OTTHUMP00000031276;OTTHUMP00000165329;OTTHUMP00000229415;activity-dependent neuroprotective protein
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- Non
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADNP-252R | Recombinant Rhesus monkey ADNP Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ADNP-365H | Recombinant Human ADNP Protein, GST-tagged | Wheat Germ | Human | GST |
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| ADNP-9008HCL | Recombinant Human ADNP 293 Cell Lysate | HEK293 | Human | Non |
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| ADNP-0118H | Recombinant Human ADNP Protein (Ala528-Thr782), N-GST-tagged | E.coli | Human | GST | Ala528-Thr782 |
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| ADNP-1701H | Recombinant Human ADNP protein, His & GST-tagged | E.coli | Human | His&GST | Ala528~Thr782 |
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| ADNP-80R | Recombinant Rhesus Macaque ADNP Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ADNP-80R-B | Recombinant Rhesus Macaque ADNP Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ADNP involved in several pathways and played different roles in them. We selected most pathways ADNP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADNP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ADNP has several biochemical functions, for example, DNA binding,beta-tubulin binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADNP itself. We selected most functions ADNP had, and list some proteins which have the same functions with ADNP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | CUTC,AOC3,TRP53,TYR,SOD1,PRNPA,COMMD1,CCC2,LOXL3A,ATOX1 |
| DNA binding | ZNF177,LHX2A,IRX1A,ZNF436,HIST1H4I,STAT2,ZNF454,LIG3,CERS4,ZFP553 |
| chromatin binding | TAF2,CIC,KDM6B,STAG1,POLR2B,MLL1,SUZ12,AJUBA,SOD3,SIRT2 |
| protein binding | GMPPA,KISS1R,C1orf189,LRP4,GTF2IRD2,S100A6,PFN2,GOLM1,FLOT2,SPAST |
| beta-tubulin binding | MAP1S,B4GALT1,GABARAPL1,SLC6A2,RANBP10,PROL1,ARL8A,SNCA,SIRT2,AKAP1 |
| peptide binding | NPFFR1L2,ERCC3,NPFFR2.1,CRIP1,GPR37L1,CRHBP,OXTR,AVPR1B,RNPEPL1,RPS6KB1 |
Interacting Protein
ADNP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADNP here. Most of them are supplied by our site. Hope this information will be useful for your research of ADNP.
CBX5;HDAC1;CBX1;CBX3;PLCG1;GAMMAHV.ORF37;CDC27;hemC;MAP1LC3B;AIM2;MYC;cona_canen;DBP;KPNA1;DYNLL1
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References
- Lei, T; Srinivasan, S; et al. Targeted Delivery of Doxorubicin by PLGA Nanoparticles Increases Drug Uptake in Cancer Cell Lines. 26TH SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE: SBEC 2010 32:224-227(2010).
- Braitch, M; Kawabe, K; et al. Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis. NEUROIMMUNOMODULATION 17:120-125(2010).
