ADD1

  • Official Full Name

    adducin 1 (alpha)

  • Overview

    Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

  • Synonyms

    ADD1;adducin 1 (alpha);alpha-adducin;erythrocyte adducin alpha subunit;ADDA;MGC3339;MGC44427

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Human
  • Chicken
  • Zebrafish
  • Rat
  • Mammalian Cell
  • E.Coli or Yeast
  • Wheat Germ
  • HEK293
  • HEK293T
  • E.coli
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADD1-1350M Recombinant Mouse ADD1 Protein Mammalian Cell Mouse His
ADD1-242R Recombinant Rhesus monkey ADD1 Protein, His-tagged Mammalian Cell Rhesus macaque His
ADD1-3338H Recombinant Human ADD1, His-tagged E.Coli or Yeast Human His 737
ADD1-336H Recombinant Human ADD1 Protein, GST-tagged Wheat Germ Human GST
ADD1-3563C Recombinant Chicken ADD1 Mammalian Cell Chicken His
ADD1-4917Z Recombinant Zebrafish ADD1 Mammalian Cell Zebrafish His
ADD1-522R Recombinant Rat ADD1 Protein Mammalian Cell Rat His
ADD1-9017HCL Recombinant Human ADD1 293 Cell Lysate HEK293 Human Non
ADD1-178R Recombinant Rat ADD1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ADD1-178R-B Recombinant Rat ADD1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ADD1-339M Recombinant Mouse ADD1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ADD1-339M-B Recombinant Mouse ADD1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ADD1-4714H Recombinant Human ADD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
ADD1-491H Recombinant Human ADD1 Protein, His-tagged E.coli Human His Thr99~Gln328
Add1-492M Recombinant Mouse Add1 Protein, His-tagged E.coli Mouse His Gly388~Gly560
Add1-539M Recombinant Mouse Add1 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
ADD1-70R Recombinant Rhesus Macaque ADD1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ADD1-70R-B Recombinant Rhesus Macaque ADD1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ADD1-907HF Recombinant Full Length Human ADD1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 662 amino acids

    Involved Pathway

    ADD1 involved in several pathways and played different roles in them. We selected most pathways ADD1 participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Programmed Cell Death PLECA,GAS2,CASP6L1,STK24A,DBNLA,Gzmg,PANK1A,RIPK3,BAXB,DSG2
    Miscellaneous transport and binding events AZGP1,EPB49,CTNS,NIPAL3,ADD2,MAGT1,PIP,ADD3B,MRS2,DMTN
    Caspase-mediated cleavage of cytoskeletal proteins PLEC,DBNLA,DBNLB,GAS2,CASP6L1,SPNA2,DBNL,PLECA,CASP6L2,VIML
    Apoptotic cleavage of cellular proteins STK26,DSG1,SATB1,CTNNB1,GAS2,PKP1,PTBP3,CASP8L1,SPNA2,DSP
    Apoptotic execution phase VIML,STK26,DNM1L,CASP8L1,HIST1H1E,HIST1H1C,BMX,DSG2,BCAP31,STK24B
    Apoptosis BAXB,RIPK1L,FASLG,DIABLOA,NFKBIAA,IRAK3,FADD,CASP3A,NFKB1,NFKBIAB
    IRE1alpha activates chaperones PREB,CTDSP2,TPP1,YIF1A,DDX11,PDIA6,ASNA1,FKBP14,SEC63,HYOU1
    Metabolism of proteins ADAMTS10,TIMM44,EXOC1,CTSH,GALNT13,TRAPPC6B,EEF1D,EXOC8,NAT8B,PIGK

    Protein Function

    ADD1 has several biochemical functions, for example, actin binding,actin filament binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD1 itself. We selected most functions ADD1 had, and list some proteins which have the same functions with ADD1. You can find most of the proteins on our site.

    Function Related Protein
    structural molecule activity CLDN15LB,SPRR2H,INAB,PRPH,LLGL1,TUBGCP3,SPRR2E,IFLTD1,CLDNC,SYNM
    protein heterodimerization activity UBA2,HIST1H2AB,BCL11A,SNX1,BRAF,FLOT1,HIST1H2AG,TAL1,ATP4A,HOMER2
    actin filament binding KLHL17,RCSD1,VPS16,TAGLN3A,VIL1,LASP1,LIMA1,USH1C,SPTA1,FSCN3
    transcription factor binding KAT2B,HMGB2,NFATC3,ARNT,MAFB,PSMD4,DNAJA3,AIP,TFDP2,ARRB1
    protein binding Abcb1b,ZBTB49,LDLRAD1,VTI1B,ARSI,PRKD1,ZRANB1,TACR3,ZNF238,SLC38A2
    actin binding XIRP1,AFAP1,CYFIP1,SSH1,MYH6,ABLIM2,EPB41L3A,SCINLA,LRRC10,TPM4
    spectrin binding CAMSAP1,GBP1,SPTAN1,GNB1,PDE6G,STX4A,USH1C,EPB49,MYO10,CAMSAP1L1
    poly(A) RNA binding SRPK1,RPS9,CKAP4,HIST1H4E,PATL1,SUGP1,SF1,HIST1H1C,TIA1,ZFP207
    protein homodimerization activity NR2F2,ACVR1,UBE4A,GRM6,HEXB,KLHL7,FGFR1OP,C6orf108,CEP57,CEACAM5

    Interacting Protein

    ADD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD1.

    RFX1;saicar;PKM;TK1;CSNK2B;ppdK;icmF1;mfd;q8czf9_yerpe;chbG;MAP1LC3B;GEMIN7;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;DST;ssdna_dtdg;TPM3

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