ADCY8
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Official Full Name
adenylate cyclase 8 (brain) -
Overview
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic;activity is under the control of several hormones, and different polypeptides participate in the transduction of the;signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G;proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the;adenylyl cyclase. -
Synonyms
ADCY8;adenylate cyclase 8 (brain);ADCY3;adenylate cyclase type 8;AC8;HBAC1;adenylyl cyclase 8;ATP pyrophosphate-lyase 8;adenylyl cyclase-8, brain;adenylate cyclase type VIII;ca(2+)/calmodulin-activated adenylyl cyclase
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- E.coli
- HEK293
- His
- GST
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
ADCY8 involved in several pathways and played different roles in them. We selected most pathways ADCY8 participated on our site, such as Activation of GABAB receptors,Activation of NMDA receptor upon glutamate binding and postsynaptic events,Adenylate cyclase activating pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of NMDA receptor upon glutamate binding and postsynaptic events | NETO2,PDPK1A,SLC14A2,CAMKK1B,ADCY1,AKAP9,DLG4,NEFLB,CREB1B,ADCY3 |
| Aquaporin-mediated transport | MIPB,AQP6,AQP11,PRKAR1AA,GNB3A,AQP10A,MYO5B,MIP,MIPA,AQP3B |
| Adenylate cyclase activating pathway | ADCY9,ADCY1,ADCY7,ADCY6,ADCY3 |
| Adrenergic signaling in cardiomyocytes | ATP1B1,PPP2R5A,CREB3L1,PPP2R2D,PLCB1,CACNA2D1,SCN1B,ADRB3B,ADRB3A,ATF2 |
| Bile secretion | SLCO1B3,SCARB1,SLC2A1,SLC22A7,ABCB11,ATP1B1,SULT2A1,HMGCR,ATP1A1,ABCG8 |
| Adenylate cyclase inhibitory pathway | ADCY3,ADCY9,ADCY7,ADCY6,ADCY1 |
| Aldosterone synthesis and secretion | GNAS,ADCY6,NR4A1,AGTR1,ATF4,CAMK2D,ITPR2,DAGLB,HSD3B2,STAR |
| Activation of GABAB receptors | GNGT2A,ADCY7,ADCY9,KCNJ2,KCNJ12,GNB3B,KCNJ9,ADCY3,GNB3A,KCNJ3 |
Protein Function
ADCY8 has several biochemical functions, for example, ATP binding,adenylate cyclase activity,calcium- and calmodulin-responsive adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY8 itself. We selected most functions ADCY8 had, and list some proteins which have the same functions with ADCY8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenylate cyclase activity | ADCY6,ADCY7,ADCY9,ADCY1,ADCY2B,GNAS,ADCY1B,ADCY1A,Adcy4,ADCY3 |
| calcium- and calmodulin-responsive adenylate cyclase activity | ADCY3,ADCY1,ADCY6 |
| ATP binding | LTK,CPS1,TRPV1,MAP2K4,SRC,ACSBG2,TXK,SGK196,MAP3K14,DDX39B |
| metal ion binding | STK24,SIRT1,KLF3,ACVR2AA,TIMM10B,NOB1,ZNF239,BIRC5,RNF207,XPA |
Interacting Protein
ADCY8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY8.
CFTR
ADCY8 Related Signal Pathway
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