ADAMTS14
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 14 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS14;ADAM metallopeptidase with thrombospondin type 1 motif, 14;A disintegrin and metalloproteinase with thrombospondin motifs 14;ADAM-TS14;ADAMTS-14;ADAM-TS 14;metalloprotease-disintegrin protease;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAMTS14-654H | Recombinant Human ADAMTS14 protein, His-tagged | E.coli | Human | His | 253-555a.a. |
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| Mhc-1343f | Recombinant fruit fly Mhc protein, His-tagged | E. coli | Human | N-His | 932-1115 aa |
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Involved Pathway
ADAMTS14 involved in several pathways and played different roles in them. We selected most pathways ADAMTS14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ADAMTS14 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS14 itself. We selected most functions ADAMTS14 had, and list some proteins which have the same functions with ADAMTS14. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ADAMTS14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS14 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS14.
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References
- Pyun, JA; Kim, S; et al. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 22:212-216(2015).
- Tota, G; Coccaro, N; et al. ADAMTS2 gene dysregulation in T/myeloid mixed phenotype acute leukemia. BMC CANCER 14:-(2014).
- Chaemsaithong, P; Madan, I; et al. Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor. JOURNAL OF PERINATAL MEDICINE 41:665-681(2013).
- Sakamoto, N; Oue, N; et al. Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma. CANCER SCIENCE 101:1038-1044(2010).
