ADAM28
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Official Full Name
ADAM metallopeptidase domain 28 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM28;ADAM metallopeptidase domain 28;MDCL;MDC-L;ADAM23;MDC-Lm;MDC-Ls;eMDCII;ADAM 28;eMDC II;disintegrin and metalloproteinase domain-containing protein 28;metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L;epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II;epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- CHO
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAM28-3003H | Recombinant Human ADAM28 protein, His-tagged | E.coli | Human | His | Glu525-Lys774 | |
| ADAM28-212H |
Active Recombinant Human ADAM28 protein, His-tagged
|
CHO | Human | His | 191-623 a.a. |
|
| ADAM28-1292M | Recombinant Mouse ADAM28 Protein | Mammalian Cell | Mouse | His |
|
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| ADAM28-3002H | Recombinant Human ADAM28, His-tagged | E.coli | Human | His | 775 |
|
| ADAM28-4560Z | Recombinant Zebrafish ADAM28 | Mammalian Cell | Zebrafish | His |
|
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| ADAM28-9036HCL | Recombinant Human ADAM28 293 Cell Lysate | HEK293 | Human | Non |
|
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| ADAM28-9037HCL | Recombinant Human ADAM28 293 Cell Lysate | HEK293 | Human | Non |
|
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| ADAM28-316M | Recombinant Mouse ADAM28 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| ADAM28-316M-B | Recombinant Mouse ADAM28 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ADAM28 involved in several pathways and played different roles in them. We selected most pathways ADAM28 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ADAM28 has several biochemical functions, for example, metalloendopeptidase activity,metallopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM28 itself. We selected most functions ADAM28 had, and list some proteins which have the same functions with ADAM28. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | SPG7,ADAM10,MMP17,YME1L1B,ADAM2,ADAMDEC1,ADAM12,ADAMTS2,Adam6,MMP3 |
| zinc ion binding | SETDB1,TRIM44,FHL5,MGRN1,SUV39H1,BPTF,GATAD1,ZNRD1,LMX1B,NR2F6A |
| metallopeptidase activity | MMP13A,CPD,XPNPEP3,MEP1A.1,CLCA5,ADAMTS4,ADAMTS9,NPSN,ADAMTS13,ACE |
Interacting Protein
ADAM28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM28 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM28.
bosutinib;imatinib
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References
- Abe, H; Mochizuki, S; et al. Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells. AMERICAN JOURNAL OF PATHOLOGY 183:1667-1678(2013).
- Mochizuki, S; Soejima, K; et al. Effect of ADAM28 on Carcinoma Cell Metastasis by Cleavage of von Willebrand Factor. JOURNAL OF THE NATIONAL CANCER INSTITUTE 104:906-922(2012).
