ADAM20
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Official Full Name
ADAM metallopeptidase domain 20 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM20;ADAM metallopeptidase domain 20;disintegrin and metalloproteinase domain-containing protein 20;ADAM 20;a disintegrin and metalloproteinase domain 20
Recombinant Proteins
- Human
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- E.coli expression system
- E. coli
- His
- GST
- N-His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAM20-9374H | Recombinant Human ADAM20, His-tagged | E.coli | Human | His | 492-693a.a. | |
| ADAM20-281H | Recombinant Human ADAM20 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| ADAM20-3001H | Recombinant Human ADAM20, His-tagged | E.coli | Human | His | 776 |
|
| ADAM20-7100C | Recombinant Chicken ADAM20 | Mammalian Cell | Chicken | His |
|
|
| ADAM20-0247H | Recombinant Human ADAM20 Protein (His367-Gly615), N-His-tagged | E.coli | Human | His | His367-Gly615 |
|
| RFL-21744HF | Recombinant Full Length Human Disintegrin And Metalloproteinase Domain-Containing Protein 20(Adam20) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (207-726) |
|
| TCEAL6-4543H | Recombinant Human TCEAL6 protein, His-tagged | E. coli | Human | N-His | 1-200 aa |
|
Involved Pathway
ADAM20 involved in several pathways and played different roles in them. We selected most pathways ADAM20 participated on our site, such as Fertilization,Interaction With The Zona Pellucida,Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fertilization | ADAM30,CATSPER3,Acr,IZUMO4,HVCN1,CATSPERB,CATSPERG2,ADAM2,CATSPER1,IZUMO1 |
| Reproduction | IZUMO4,OVGP1,HVCN1,ZP3,CATSPERG1,IZUMO1,Acr,ADAM2,CATSPERG2,TMEM146 |
| Interaction With The Zona Pellucida | ADAM21,ADAM2,OVGP1,ZP3,ADAM30,ZP2 |
Protein Function
ADAM20 has several biochemical functions, for example, metalloendopeptidase activity,metallopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM20 itself. We selected most functions ADAM20 had, and list some proteins which have the same functions with ADAM20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | SH3RF2,PAM,ZNF207,RNF149,CPDB,PHC3,PAPLN,ZDHHC1,ZSWIM1,PAPPA2 |
| metalloendopeptidase activity | ADAM18,MMP7,MMP12,MEP1A.1,PAPPAA,ADAM5P,MMP1,ADAM7,MMP2,ADAMTS15A |
| metallopeptidase activity | MMP14B,ADAM10B,DNPEP,MMP9,ADAMTS7,YME1L1,ADAM17,ADAMTSL3,C6AST3,ADAM18 |
Interacting Protein
ADAM20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM20 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM20.
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References
- Zhang, X; Wang, J; et al. EFFECTS OF GINSENOSIDE RG1 OR 17 beta-ESTRADIOL ON A COGNITIVELY IMPAIRED, OVARIECTOMIZED RAT MODEL OF ALZHEIMER'S DISEASE. NEUROSCIENCE 220:191-200(2012).
- Parry, DA; Toomes, C; et al. Loss of the Metalloprotease ADAM9 Leads to Cone-Rod Dystrophy in Humans and Retinal Degeneration in Mice. AMERICAN JOURNAL OF HUMAN GENETICS 84:683-691(2009).
