ADAM18
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Official Full Name
ADAM metallopeptidase domain 18 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADAM18;ADAM metallopeptidase domain 18;a disintegrin and metalloproteinase domain 18;disintegrin and metalloproteinase domain-containing protein 18;putative ADAM18 gene product;ADAM27;tMDCIII;disintegrin and metalloproteinase domain-containing prot
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAM18-9371H | Recombinant Human ADAM18, His-tagged | E.coli | Human | His | 338-687a.a. | |
| ADAM18-1280M | Recombinant Mouse ADAM18 Protein | Mammalian Cell | Mouse | His |
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| ADAM18-309M | Recombinant Mouse ADAM18 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ADAM18-309M-B | Recombinant Mouse ADAM18 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| PRRG4-5037H | Recombinant Human PRRG4 protein, GST-tagged | E. coli | Human | N-GST | 144-226 aa |
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Involved Pathway
ADAM18 involved in several pathways and played different roles in them. We selected most pathways ADAM18 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ADAM18 has several biochemical functions, for example, metalloendopeptidase activity,metallopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM18 itself. We selected most functions ADAM18 had, and list some proteins which have the same functions with ADAM18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | UQCRC2B,MMP15,MMP19,PMPCB,ECE2,ADAMTS2,ADAMTS20,ADAM21,BMP1,ADAMTS15 |
| metallopeptidase activity | BMP1B,NAALAD2,ADAM8,PAPPAA,CLCA5,ECEL1,STAMBPL1,DPP3,ADAM12,ERAP2 |
| zinc ion binding | TRIP6,TRIM50,CXXC1B,UBR3,ZNF330,EWSR1,LDB3,PDLIM3,ADAMDEC1,APOBEC3F |
Interacting Protein
ADAM18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM18.
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