ACTG1
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Official Full Name
actin, gamma 1 -
Overview
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants. -
Synonyms
ACTG1;actin, gamma 1;ACTG, deafness, autosomal dominant 20;deafness, autosomal dominant 26 , DFNA20, DFNA26;actin, cytoplasmic 2;cytoplasmic 2;N-terminally processed;ACT;ACTB;ACTG;ACTG_HUMAN;Actin;Actin, gamma 1 propeptide;Cytoskeletal gamma actin;Deafness, autosomal dominant 20;Deafness, autosomal dominant 26;DFNA20;DFNA26;Gamma-actin;cytoskeletal gamma-actin
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- Mammalian Cell
- E.coli
- Wheat Germ
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- T7
- GST
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
ACTG1 involved in several pathways and played different roles in them. We selected most pathways ACTG1 participated on our site, such as Rap signaling pathway,Phagosome,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | PGF,DIAPH1,PAK2,LAMA4,ITGB1,PIK3CG,ACTN3A,MYL5,PTEN,SHC1 |
| Hypertrophic cardiomyopathy (HCM) | CACNG4,TPM4,LAMA2,CACNA2D2,ITGA6,ITGA2,IL6,CACNG3,ITGA10,DES |
| Platelet activation | LCP2,ROCK2,F2R,MAPK13,MAPK12,P2RX1,ARHGEF1,VAMP8,MYLK3,ITGA2 |
| Regulation of Actin Cytoskeleton | ACTB2,RHOAD,BRAF,PAK2,CYFIP1,SSH2,FGF5,MAP2K1,ITGA9,MYLK4 |
| Tight junction | JAM2A,LLGL1,MYLPFA,CLDN15LA,CLDNH,CLDN18,CASK,SHROOM3,ASH1L,SHROOM1 |
| Rap signaling pathway | INS,PIK3R2,FIGF,KRIT1,MAPK1,Pdgfa&Pdgfb,PARD6A,NGF,INSR,MAP2K6 |
| Salmonella infection | IFNGR1,PFN4,NFKB1,RHOGD,PKN1,MYH10,RILP,PKN3,IL1A,PYCARD |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGB1,CTNNA3,TCF7L2,CACNA2D4,LAMA2,LEF1,CTNNA1,SGCG,ACTN1,ITGB4 |
| Proteoglycans in cancer | TGFB1,WNT5A,SLC9A1,PPP1CA,VEGFA,ARHGEF12,PIK3R3,FLNA,PRKACB,HIF1A |
Protein Function
ACTG1 has several biochemical functions, for example, ATP binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTG1 itself. We selected most functions ACTG1 had, and list some proteins which have the same functions with ACTG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TEAD1,PLCE1,IL17A,CAST,HIST1H2BF,ZNF114,SMN1,PPIH,CLPTM1,MYOD1 |
| ATP binding | DDX39AA,MYH7B,MASTL,KIF2C,KARS,OXSR1B,WEE1,GUCY2F,MOV10,CKMT2A |
| identical protein binding | KCNIP2,ASMT,APPL1,DCP1A,EDC3,LYZ,IGF1R,PSMA7,ROBO2,L3MBTL1 |
| structural constituent of cytoskeleton | TUBA3D,TUBG1,ADD3,ATXN1,KRT17,TUBA4L,TUBB4B,ARPC3,TUBA1B,CTNNA2 |
| ubiquitin protein ligase binding | ATP6V0C,TUBA1B,HIF1A,PER1,USP13,KCNH2,H2-AB1,CUL1,DAXX,PRKACA |
Interacting Protein
ACTG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTG1.
ACTB;DSTN;CFL1
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References
- Verloes, A; Di Donato, N; et al. Baraitser-Winter cerebrofrontofacial syndrome: delineation of the spectrum in 42 cases. EUROPEAN JOURNAL OF HUMAN GENETICS 23:292-301(2015).
- Marques, F; Heredia, R; et al. Partial Trisomy 17q and Partial Monosomy 20q in a Boy with Craniosynostosis. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:412-416(2015).
