ACSS2
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Official Full Name
acyl-CoA synthetase short-chain family member 2 -
Overview
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. -
Synonyms
ACSS2;acyl-CoA synthetase short-chain family member 2;ACAS2, acetyl Coenzyme A synthetase 2 (ADP forming);acetyl-coenzyme A synthetase, cytoplasmic;AceCS;ACS;ACSA;dJ1161H23.1;cytoplasmic;ACAS2;Acetate CoA ligase;Acetate thiokinase;Acetate--CoA ligase;Acetyl CoA synthetase;Acetyl Coenzyme A synthetase 2 (ADP forming);Acetyl coenzyme A synthetase cytoplasmic;Acetyl-CoA synthetase;Acetyl-coenzyme A synthetase;ACSA_HUMAN;Acyl activating enzyme;Acyl CoA synthetase short chain family member 2;Acyl-activating enzyme;Cytoplasmic acetyl coenzyme A synthetase;MYH7B;acetate-CoA ligase;cytoplasmic acetyl-coenzyme A synthetase;acetyl-Coenzyme A synthetase 2 (ADP forming)
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- E. coli
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
- N-His
Involved Pathway
ACSS2 involved in several pathways and played different roles in them. We selected most pathways ACSS2 participated on our site, such as Glycolysis / Gluconeogenesis,Pyruvate metabolism,Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | ALDH2.1,ALDH9A1A.1,PFKM,ALDH1A3,PFKP,ENO1B,DLDH,GM5506,PKLR,G6PC |
| Pyruvate metabolism | ME1,ACOT12,SLC16A8,PCK2,PDHA2,PDHA1A,hchA,HAGHL,PKM2,BRP44 |
| Propanoate metabolism | DLDH,ALDH6A1,BCKDHA,LDHA,LDHBA,ACADM,MLYCD,ECHDC1,MCEE,PCCB |
| Carbon metabolism | PDHB,GAPDH,FBP1,FBP1B,GPT2,HIBCH,DAK,ME1,PDHA1,TPI1A |
| Metabolic pathways | CDS1,ENO1A,MGAT1A,CAD,FAHD1,PKM,CNDP2,COX11,TPI1B,PDXKB |
Protein Function
ACSS2 has several biochemical functions, for example, AMP binding,ATP binding,acetate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSS2 itself. We selected most functions ACSS2 had, and list some proteins which have the same functions with ACSS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAP4K2,ATP7B,NUBPL,ACTA1A,ERBB4,ABCG2,RPS6KC1,DHX16,ERBB4A,GMPS |
| AMP binding | PYGL,APRT,PRPS1,ACSS1,PRKAG2,PYGM,PRPS2,CYB5R3,PRKAG1,FBP1 |
| acetate-CoA ligase activity | ACSS1,ACSS3 |
Interacting Protein
ACSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSS2.
q2i360_hbv;purT;UPF1;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;Smchd1;CTR9
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