ACOX3
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Official Full Name
acyl-CoA oxidase 3, pristanoyl -
Overview
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes.Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements.However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. -
Synonyms
ACOX3;acyl-CoA oxidase 3, pristanoyl;acyl Coenzyme A oxidase 3, pristanoyl;peroxisomal acyl-coenzyme A oxidase 3;Acyl-CoA oxidase, pristanoyl, peroxisomal;Acyl-Coenzyme A oxidase 3, pristanoyl;Branched-chain acyl-CoA oxidase;BRCACox;BRCOX;EST-s59;PCOX;Pristanoyl-CoA oxidase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- E. coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- N-His
- His
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ACOX3 involved in several pathways and played different roles in them. We selected most pathways ACOX3 participated on our site, such as Fatty acid degradation,alpha-Linolenic acid metabolism,Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | CALM3,MAP2K2,F2R,GRIN3A,NFKBIA,MAPK3,RELA,ROCK1,OXTR,RAC2 |
| Biosynthesis of unsaturated fatty acids | ACOT7,TECR,BAAT,HADHAA,HSD17B12B,ELOVL2,PTPLAD2,PTPLA,ACOT5,TECRB |
| alpha-Linolenic acid metabolism | PLA2G2D,PLA2G1B,PLA2G3,PLA2G4F,PLA2G10,PLA2G4AA,PLA2G2E,ACAA1A,ACOX1,PLA2G12A |
| PPAR signaling pathway | DBI,RXRB,CYP7A1A,PPARG,SCDB,ACSL5,ACSL4A,APOA1,RXRBA,OLR1 |
| Metabolic pathways | PI4KAA,PAFAH1B1,TPH1B,IDH3G,CYP3A7-CYP3AP1,FUT8,UCK2,ADC,HSD17B2,MVK |
| Fatty acid degradation | HADHB,ACSL3,CYP4A14,ALDH1B1,ALDH9A1B,ECI1,ALDH9A1A.1,GCDHB,ACAA1,ACSL4 |
| Peroxisome | NOS2,HMGCL,PEX11B,PXMP2,PEX6,PXMP4,ACSL4,IDH1,AGXTA,SLC27A2 |
| Fatty acid metabolism | ELOVL5,HADH,PPT1,ELOVL2,FADS2,HADHA,CPT1B,ACAT2,HADHAB,SCD |
Protein Function
ACOX3 has several biochemical functions, for example, acyl-CoA dehydrogenase activity,electron carrier activity,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOX3 itself. We selected most functions ACOX3 had, and list some proteins which have the same functions with ACOX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pristanoyl-CoA oxidase activity | ACOXL,ACOX2 |
| flavin adenine dinucleotide binding | CYBB,TXNRD1,MAOA,SDHA,MTO1,ACOX2,AOX3,AOX4,ACADVL,ACAD8 |
| fatty-acyl-CoA binding | ACBD5B,ACBD4,ACOT7,ACADM,ACBD5,ACAD8,GCDH,GCDHB,ACBD7,ACAD9 |
| receptor binding | ANKRD13C,ACOT2,GBA,CD276,GRIN2A,KCNA5,FGF18B,GNB2L1,KNG1,SNX17 |
| acyl-CoA dehydrogenase activity | ACOX2,ACOX1,ETFA,ACADVL,ACAD9,ACADL,ACADM,ACADS,ACADSB,GCDHA |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACADVL,ACOX2,ACOX1,IVD,GCDHB,GCDHA,ACAD11,ETFA,ACOXL,ACADL |
| electron carrier activity | CYP1A2,HAAO,COX7A3,CIAPIN1,ME1,ACAD11,IVD,ACOX1,GLDC,NDUFA12 |
Interacting Protein
ACOX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOX3.
SMURF2;bosutinib;imatinib;dasatinib
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References
- Westin, MAK; Hunt, MC; et al. Peroxisomes contain a specific Phytanoyl-CoA/Pristanoyl-CoA thioesterase acting as a novel auxiliary enzyme in alpha- and beta-oxidation of methyl-branched fatty acids in mouse. JOURNAL OF BIOLOGICAL CHEMISTRY 282:26707-26716(2007).
