ACOT8
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Official Full Name
acyl-CoA thioesterase 8 -
Overview
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. -
Synonyms
ACOT8;acyl-CoA thioesterase 8;peroxisomal acyl CoA thioesterase , peroxisomal acyl CoA thioesterase 1 , PTE1;acyl-coenzyme A thioesterase 8;choloyl CoA hydrolase;hACTE III;hTE;PTE 2;ACTEIII;ACOT8_HUMAN;acyl CoA thioesterase 8;Choloyl coenzyme A thioesterase;Choloyl-coenzyme A thioesterase;hACTE-III;hACTEIII;HIV Nef associated acyl CoA thioesterase;HIV-Nef-associated acyl-CoA thioesterase;HNAACTE;Long chain fatty acyl CoA hydrolase;Palmitoyl CoA hydrolase;Peroxisomal acyl CoA thioesterase 1;Peroxisomal acyl coenzyme A thioester hydrolase 1;Peroxisomal acyl-coenzyme A thioester hydrolase 1;Peroxisomal long chain acyl CoA thioesterase 1;Peroxisomal long-chain acyl-CoA thioesterase 1;PTE 1;PTE-1;PTE-2;PTE1;PTE2;Thioesterase II;thioesterase III;OTTHUMP00000031675;OTTHUMP00000214962;choloyl-CoA hydrolase;palmitoyl-CoA hydrolase;long-chain fatty-acyl-CoA hydrolase;peroxisomal acyl-CoA thioesterase 1;HIV
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rhesus macaque
- Mammalian Cells
- Wheat Germ
- E.Coli/Yeast
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACOT8-1206M | Recombinant Mouse ACOT8 Protein | Mammalian Cells | Mouse | His |
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| ACOT8-1581Z | Recombinant Zebrafish ACOT8 | Mammalian Cells | Zebrafish | His |
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| ACOT8-170H | Recombinant Human ACOT8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ACOT8-213R | Recombinant Rhesus monkey ACOT8 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| Acot8-3140M | Recombinant Mouse Acot8, His-tagged | E.Coli/Yeast | Mouse | His | 320 |
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| ACOT8-3141H | Recombinant Human ACOT8, His-tagged | E.Coli/Yeast | Human | His | 319 |
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| ACOT8-7604H | Recombinant Human ACOT8, His-tagged | E.coli | Human | Non | 1-319aa |
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| ACOT8-9086HCL | Recombinant Human ACOT8 293 Cell Lysate | HEK293 | Human | Non |
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| ACOT8-259M | Recombinant Mouse ACOT8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ACOT8-259M-B | Recombinant EPCAM-coupled magnetic beads | HEK293 | Mouse |
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| ACOT8-41R | Recombinant Rhesus Macaque ACOT8 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ACOT8-41R-B | Recombinant Rhesus Macaque ACOT8 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ACOT8-793HF | Recombinant Full Length Human ACOT8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 319 amino acids |
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| ACOT8-906H | Recombinant Human ACOT8 Protein, His-tagged | E.coli | Human | His |
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Involved Pathway
ACOT8 involved in several pathways and played different roles in them. We selected most pathways ACOT8 participated on our site, such as Beta-oxidation of pristanoyl-CoA,Beta-oxidation of very long chain fatty acids,Bile acid and bile salt metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | YY2,STARD5,CYP51A1,VAPB,ADAL,FABP1B.1,CYP27A1,BHMT2,PLB1,FIG4 |
| Metabolic pathways | COX11,CBR1,POLR1D,PIP5K1BA,ATP6V0A1,POLR2I,FBP1A,NT5C3A,NDUFA5,HEXA |
| Fatty acid, triacylglycerol, and ketone body metabolism | YAP1,MED7,MED16,MED15,TIAM2,ELOVL1A,ACAD11,G0S2,AGPAT1,DGAT1B |
| Bile acid and bile salt metabolism | CYP46A1,Alb,AKR1C4,SCP2B,SLCO1B1,CYP27A1,CYP8B2,AKR1C2,SLC27A5,SLC27A2A |
| Beta-oxidation of pristanoyl-CoA | CRAT,SCP2B |
| Fatty Acyl-CoA Biosynthesis | ACOT9.2,ACOT11A,ACOT10,ELOVL1A,ACOT12,ACOT9,ACOT6,ACSF2,ACOT9.1,ACOT2 |
| Beta-oxidation of very long chain fatty acids | CRAT |
| Metabolism of lipids and lipoproteins | PNPLA8,APOEA,PMVK,ARF3,CHKA,COQ6,SACM1LB,CYP8B2,FA2H,ACOT13 |
Protein Function
ACOT8 has several biochemical functions, for example, acyl-CoA hydrolase activity,carboxylic ester hydrolase activity,choloyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT8 itself. We selected most functions ACOT8 had, and list some proteins which have the same functions with ACOT8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acyl-CoA hydrolase activity | ACOT5,ACOT10,ACOT11,ACOT1,ACOT2,ACSBG2 |
| medium-chain acyl-CoA hydrolase activity | BAAT |
| protein binding | LIPE,CDC42BPA,MRPL28,COMMD1,FKBP3,KDM4A,TFIP11,TSSK6,PITX2,MAPK4 |
| receptor binding | Ar,FGF12A,FGF24,RARRES2,NRG2B,NPPB,HLA-G,RND1,CRTAM,SSTR3 |
| carboxylic ester hydrolase activity | CES3A,ABHD11,CES1C,Ces2e,CES1D,ACOT1,FAM135A,PNPLA7,ABHD2,BAAT |
| palmitoyl-CoA hydrolase activity | ACOT2,ACOT7,ACOT1,GNPAT,PPT1,THEM4,ACOT5,THEM5,BAAT |
Interacting Protein
ACOT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT8.
nef;PEX5;REL;15-deoxy-delta(12,14;midostaurin;MYC;US3;Nedd1;P
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