ACADM
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Official Full Name
acyl-CoA dehydrogenase, C-4 to C-12 straight chain -
Overview
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ACADM;acyl-CoA dehydrogenase, C-4 to C-12 straight chain;acyl Coenzyme A dehydrogenase, C 4 to C 12 straight chain;medium-chain specific acyl-CoA dehydrogenase, mitochondrial;ACAD1;MCAD;MCADH;acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chai
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ACADM involved in several pathways and played different roles in them. We selected most pathways ACADM participated on our site, such as Fatty acid degradation,Valine, leucine and isoleucine degradation,beta-Alanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACADM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | HMGCS2,ACAT1,AUH,HADH,ALDH6A1,HIBCH,AOX2P,ALDH3A2,ACAA1A,DLDH |
| PPAR signaling pathway | CYP4A10,DBI,SCD5,APOC3,ACSL4B,PPARD,SLC27A4,ME1,FADS2,RXRB |
| Carbon metabolism | FBP1A,ADH5,PGLS,DLDH,PFKP,AMT,ESD,SUCLA2,PDHA1A,HAO1 |
| beta-Alanine metabolism | ALDH3A1,SRM,SMOX,ALDH7A1,DPYDB,ALDH2,GAD1,CARNS1,ALDH9A1,ALDH9A1A.1 |
| Propanoate metabolism | ACSS2L,DLDH,ECHDC1,LDHBB,HADHAA,ALDH6A1,MCEE,LDHC,BCKDHA,PCCA |
| Fatty acid degradation | CPT1A,EHHADH,HADH,ALDH7A1,ACADL,ACSL1B,ALDH2,ACAA1A,ADH7,ADH1 |
| Metabolic pathways | ALAS1,ST6GALNAC6,EPHX2,PON2,MT-ATP6,FAH,UGP2A,NDUFB8,GGT1,ENO3 |
| Fatty acid metabolism | SCDB,CPT1A,TECR,ACADSB,Scd2,PTPLAD1,MECR,HADHAB,ACADS,HSD17B12A |
Protein Function
ACADM has several biochemical functions, for example, acyl-CoA dehydrogenase activity,electron carrier activity,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACADM itself. We selected most functions ACADM had, and list some proteins which have the same functions with ACADM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acyl-CoA dehydrogenase activity | ACADS,ACAD9,ACOXL,ACAD8,ACADL,GCDHB,ACOX1,ACADVL,GCDHA,ACADSB |
| electron carrier activity | AOX3L1,GLDC,P4HA2,QDPR,TSTA3,PTGESL,NDUFS2,NDUFS1,ALDH4A1,PRKRA |
| identical protein binding | ECI1,DPP9,RAF1,LEPR,SIAH1A,CBLL1,ESYT2,KCTD13,COL7A1,DACT3 |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ETFA,ACADVL,ACAD9,ACAD11,ACADSB,ACAD8,ACADL,GCDHB,IVD,ACOX3 |
| fatty-acyl-CoA binding | SCP2,ACAD11,ACOX3,ACBD7,DBIL5,GCDHB,ACBD5B,ECI2,ACBD5,IVD |
| medium-chain-acyl-CoA dehydrogenase activity | RSAD1,ACAD11 |
| flavin adenine dinucleotide binding | FMO2,GFER,ACOX1,ACAD11,ACOXL,FOXRED2,TXNRD2,ACOX2,CHDH,GULO |
Interacting Protein
ACADM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACADM here. Most of them are supplied by our site. Hope this information will be useful for your research of ACADM.
USP50;USP20;trmn6_yerpe;guaA;HDAC1;CLPP;GABARAPL1
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References
- Baik, M; Nguyen, TH; et al. Effects of Castration on Expression of Lipid Metabolism Genes in the Liver of Korean Cattle. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:127-134(2015).
