ABR
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Official Full Name
active BCR-related gene -
Overview
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis, suggesting that Rho-related GTPases help coordinate motor skills and balance. Alternatively spliced transcript variants that encode different isoforms have been reported for this gene. -
Synonyms
ABR;active BCR-related gene;active breakpoint cluster region-related protein;MDB;Active BCR related gene;Active breakpoint cluster region related protein
Recombinant Proteins
- Mouse
- Human
- Bovine
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- E.coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABR-1148M | Recombinant Mouse ABR Protein | Mammalian Cell | Mouse | His |
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| ABR-115H | Recombinant Human ABR Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABR-116H | Recombinant Human ABR Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABR-3116B | Recombinant Bovine ABR, His-tagged | E.Coli or Yeast | Bovine | His | 859 |
|
| ABR-9122HCL | Recombinant Human ABR 293 Cell Lysate | HEK293 | Human | Non |
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| ABR-226M | Recombinant Mouse ABR Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ABR-226M-B | Recombinant Mouse ABR Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ABR-301435H | Recombinant Human ABR protein, GST-tagged | E.coli | Human | GST | Met1-Lys87 |
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| Abr-445M | Recombinant Mouse Abr Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ABR-5357H | Recombinant Human ABR Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| ABR-835HF | Recombinant Full Length Human ABR Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 859 amino acids |
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Involved Pathway
ABR involved in several pathways and played different roles in them. We selected most pathways ABR participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rho GTPase cycle | MYO9B,CHN2,FAM13A,ECT2,ARAP2,ARHGAP25,STARD13,RHOU,ARHGEF18,ARHGAP12B |
| G alpha (12/13) signalling events | FGD4A,GNA13B,MCF2L,FGD4,ARHGEF16,ADRA1D,ARHGEF18,TRIO,PLEKHG2,ECT2 |
| Signal Transduction | STRA6,MKL1,TAAR1,RSPO4,RSPO2,OXGR1A.3,SRY,NMT1A,EMR4,ARHGAP20 |
| Regulation of RhoA activity | ARHGEF10,ARHGEF25,OBSCN,DEF6,MYO9B,NET1,ARHGAP4,ARHGEF18,ARAP1,ARHGEF28 |
| GPCR downstream signaling | RGS7,RHOGA,TAC2,TAS2R7,DCLRE1B,OXGR1A.2,LPAR2A,CCR9,CRH,S1PR3 |
| Cell death signalling via NRAGE, NRIF and NADE | TRIO,BCL2L11,KALRN,ARHGEF9,ITSN1,AKAP13,ARHGEF17,OBSCN,ITGB3BP,FGD4A |
| NRAGE signals death through JNK | ARHGEF18,ARHGAP4,PLEKHG2,ARHGEF3,AATF,ARHGEF18A,FGD2,NET1,ECT2,FGD4A |
| Regulation of RAC1 activity | ARHGAP17,RAP1GDS1,DEF6,PREX2,ARHGAP9,EPS8,DOCK6,ARHGAP1,RALBP1,CHN2 |
Protein Function
ABR has several biochemical functions, for example, GTPase activator activity,Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABR itself. We selected most functions ABR had, and list some proteins which have the same functions with ABR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | CDC42EP1B,RGS11,TBC1D9B,GARNL3,GRTP1A,ARHGAP36,TBC1D24,RGS9A,WNT11,FAM13B1 |
| Rho guanyl-nucleotide exchange factor activity | VAV2,ARHGEF7,FGD4A,PLEKHG4,ARHGEF1B,TRIOA,C3A.1,OBSCN,ITSN2,ARHGEF15 |
Interacting Protein
ABR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABR here. Most of them are supplied by our site. Hope this information will be useful for your research of ABR.
Dlg4;ABL1;ADRA1A;pi3p
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References
- Kavakli, K; Yang, R; et al. Prophylaxis vs. on-demand treatment with BAY 81-8973, a full-length plasma protein-free recombinant factor VIII product: results from a randomized trial (LEOPOLD II). JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13:360-369(2015).
- Urasinski, T; Stasyshyn, O; et al. Recombinant factor IX (BAX326(1)) in previously treated paediatric patients with haemophilia B: a prospective clinical trial. HAEMOPHILIA 21:196-203(2015).
