ABCG8
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 8 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. -
Synonyms
ABCG8;ATP-binding cassette, sub-family G (WHITE), member 8;ATP binding cassette, sub family G (WHITE), member 8 (sterolin 2);ATP-binding cassette sub-family G member 8;gallbladder disease 4;GBD4;sterolin 2;sterolin-2;ATP-binding cassette, subfamil
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Arabidopsis thaliana
- Mus musculus
- Dictyostelium Discoideum
- E. coli
- Wheat Germ
- Mammalian Cell
- E.Coli or Yeast
- E.coli
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- N-His
- N-GST
- Non
- His
- His&T7
- His&Fc&Avi
- GST
Involved Pathway
ABCG8 involved in several pathways and played different roles in them. We selected most pathways ABCG8 participated on our site, such as ABC transporters,Fat digestion and absorption,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fat digestion and absorption | PNLIP,ACAT2,PLA2G12B,PPAP2C,MTTP,SLC27A4,CLPS,Cel,PLA2G2F,AGPAT1 |
| ABC transporters | ABCB1A,ABCB6A,ABCA9,ABCD2,ABCB8,ABCC8,ABCC3,Abca2,ABCA3,ABCA13 |
| Bile secretion | CA2,SLC51A,SLC10A1,SLCO1B2,KCNN2,SLC51B,ADCY8,ABCC2,SLC2A1,AQP4 |
Protein Function
ABCG8 has several biochemical functions, for example, contributes_to ATP binding,contributes_to ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG8 itself. We selected most functions ABCG8 had, and list some proteins which have the same functions with ABCG8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATPase activity | ATP5H,ATP5C1,ATP5B,ATP1B1,ABCA7,ATP5J,ATP5J2,RUVBL2,ATP5I,ATP5O |
| protein binding | MLF1,ACACB,CDC42BPA,CDKAL1,NUP50,GPANK1,ARL4C,DEF6,DNAAF2,KCNIP2 |
| contributes_to ATP binding | ATP1A2,ATP1B1,SFRP5,MSH2,ATP5D,MSH6 |
| protein heterodimerization activity | TOP2B,CENPA,KCNH5,SYT10,MAPK4,HIST1H2BA,PHC2B,BOK,HSPD1,DR1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCG2A,ABCD3A,ABCC10,ABCC6,ABCC12,ABCB5,ABCC3,SFRP5,ABCA7,ABCB1 |
| contributes_to cholesterol transporter activity | SFRP5,APOA1,APOA2,ABCG5 |
Interacting Protein
ABCG8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG8.
ABCG5;AGPAT2;NUPR1;ANG;LMNB1;NR4A1;AKT2;MAL2
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References
- Kumar, P; Raghavan, S; et al. Ligation of RAGE with ligand S100B attenuates ABCA1 expression in monocytes. METABOLISM-CLINICAL AND EXPERIMENTAL 62:1149-1158(2013).
- Hirschfield, GM; Chapman, RW; et al. REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. GASTROENTEROLOGY 144:1357-1374(2013).
