ABCG5
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 5 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008] -
Synonyms
ABCG5;ATP-binding cassette, sub-family G (WHITE), member 5;STSL;ATP-binding cassette sub-family G member 5;sterolin 1;sterolin-1;ATP-binding cassette, subfamily G, member 5
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Mus musculus
- Human
- Arabidopsis thaliana
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- His&T7
- His&Fc&Avi
Involved Pathway
ABCG5 involved in several pathways and played different roles in them. We selected most pathways ABCG5 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB3L1,ABCB5,ABCC1,SUR2A,ABCA7,ABCC10,ABCA1,ABCD3A,ABCA8,ABCD2 |
Protein Function
ABCG5 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG5 itself. We selected most functions ABCG5 had, and list some proteins which have the same functions with ABCG5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to cholesterol transporter activity | ABCG8,APOA2,APOA1,SFRP5 |
| ATP binding | LMTK2,EIF4A1,CDK13,ENTPD8,MVDA,ROR1,DDX39A,CAMK1D,RPS6KC1,MB21D1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCG2D,ABCC6,ABCC2,ABCG2,ABCD3A,ABCD1,ABCB4,ABCA9,ABCA1B,IPO8 |
| nucleotide binding | ATP2A2A,RBMS2,SRSF2B,RBPMS2,TUBA8L2,NAIP1,NT5M,RBFOX1L,STK25A,ABT1 |
| ATPase activity | IDE,ABCB6A,ABCA5,DNAHC8,ABCG4B,CLPB,MYH9,ABCG2B,ATF7IP,NSFB |
Interacting Protein
ABCG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG5.
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References
- Klett, EL; Lee, MH; et al. Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC GASTROENTEROLOGY 4:-(2004).
- Yoon, JH; Choi, HS; et al. ATP-Binding Cassette Sterol Transporters Are Differentially Expressed in Normal and Diseased Human Gallbladder. DIGESTIVE DISEASES AND SCIENCES 58:431-439(2013).
- Cassio, D; Macias, RIR; et al. Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3-1 and Can 10. CELL AND TISSUE RESEARCH 330:447-460(2007).
