ABCC8
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -
Overview
The protein encoded by the SUR1 gene is a member of the superfamily of ATP-binding cassette . No disease has been associated with this gene thus far. -
Synonyms
ABCC8;ATP-binding cassette, sub-family C (CFTR/MRP), member 8;sulfonylurea receptor;Sur;SUR1;D930031B21Rik
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293T
- HEK293
- Mammalian cells
- His
- GST
- His&T7
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
ABCC8 involved in several pathways and played different roles in them. We selected most pathways ABCC8 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB6,ABCC4,ABCB5,ABCA13,ABCD4,ABCB4,ABCG1,ABCA1B,ABCG3,ABCG5 |
Protein Function
ABCC8 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC8 itself. We selected most functions ABCC8 had, and list some proteins which have the same functions with ABCC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity | KIF25,BLM,EIF4A1B,ENTPD2,PMS2,DNA2,ABCB4,TOR1B,DNAH11,ABCC5 |
| nucleotide binding | PUF60,SRSF2,SF3B6,RAB12,RBM4.2,ACTA1A,NPR1A,IFT22,STK25B,CAMK2D1 |
| ATP binding | MADD,CNTN1B,PIK3R4,MLH3,MAPK8,OAS1,EEF2K,ABCD3,TUT1,Adcy4 |
| ATPase activity, coupled to transmembrane movement of substances | TAP1,ABCA7,ABCB6A,ABCD4,ABCD3B,DPY19L2,ABCA13,ABCA4,ABCD1,ABCA1B |
| sulfonylurea receptor activity | ABCC9 |
Interacting Protein
ABCC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC8.
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References
- Alves, C; Constanca, J; et al. A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 26:1163-1166(2013).
- Irgens, HU; Molnes, J; et al. Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. DIABETOLOGIA 56:1512-1519(2013).
