ABCC5
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. -
Synonyms
ABCC5;ATP-binding cassette, sub-family C (CFTR/MRP), member 5;multidrug resistance-associated protein 5;EST277145;MOAT C;MRP5;SMRP;ATP-binding cassette sub-family C member 5;multi-specific organic anion transporter C;canalicular multispecific org
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E. coli
- Wheat Germ
- Mammalian Cell
- Mammalian cell
- HEK293
- In Vitro Cell Free System
- N-His
- GST
- His
- His&StrepII&EGFP
- His&Fc&Avi
Involved Pathway
ABCC5 involved in several pathways and played different roles in them. We selected most pathways ABCC5 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCA1B,ABCC6,ABCB7,ABCC9,ABCC10,ABCC11,ABCC4,ABCB11,ABCA1,ABCB1 |
Protein Function
ABCC5 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC5 itself. We selected most functions ABCC5 had, and list some proteins which have the same functions with ABCC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity, coupled to transmembrane movement of substances | ABCA4,ABCC10,ATP6V1D,ABCB10,Abca2,ABCC3,ABCD3A,ABCC2,ABCC1,ABCB5 |
| organic anion transmembrane transporter activity | SLC22A31,SLCO1B3,SLCO1B2,SLCO4C1,SLC22A17,SLCO3A1,SLC22A20,SLCO1A4,SLC17A3,ABCC3 |
| ATPase activity | EIF4A1B,PSMC6,ABCB6,KIF9,CLPX,PSMD6,ABCG2A,CENPE,PSMC3,KIFC2 |
| nucleotide binding | GDPGP1,PRAC,HINT1,RHOAC,ATP2B1B,RBM14A,MYH11A,UBE2L3A,MAT2AL,SRSF2A |
| ATP binding | CDK8,MAPKAPK2B,KIFC2,TUT1,DNAH14,DYNC1LI1,MYHZ1.2,PIK3C2A,STK16,VCP |
Interacting Protein
ABCC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC5.
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References
- Li, Y; Revalde, JL; et al. Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells. CANCER CHEMOTHERAPY AND PHARMACOLOGY 68:603-610(2011).
- Aye, ILMH; Paxton, JW; et al. Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes. PLACENTA 28:868-877(2007).
