ABAT
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Official Full Name
4-aminobutyrate aminotransferase -
Overview
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. -
Synonyms
ABAT;4-aminobutyrate aminotransferase;4-aminobutyrate aminotransferase, mitochondrial;4 aminobutyrate transaminase;GABAT;mitochondrial;(S) 3 amino 2 methylpropionate transaminase;(S)-3-amino-2-methylpropionate transaminase;4 aminobutyrate aminotransferase;4 aminobutyrate aminotransferase, mitochondrial;FLJ17813;FLJ30272;GABA aminotransferase;GABA AT;GABA T;GABA transaminase;GABA transferase;GABA-AT;GABA-T;GABT_HUMAN;Gamma amino N butyrate transaminase;Gamma-amino-N-butyrate transaminase;hCG1984265;L AIBAT;L-AIBAT;LAIBAT;NPD009;4-aminobutyrate transaminase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His&T7
- His
- His&Myc&SUMO
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ABAT involved in several pathways and played different roles in them. We selected most pathways ABAT participated on our site, such as 4-aminobutanoate degradation I,4-aminobutyrate degradation,Alanine and aspartate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | DDO,GOT2B,AGXTA,GOT1,GLULC,GAD1B,GFPT1,AGXTB,IL4I1,ADSSL |
| Butanoate metabolism | OXCT2B,OXCT1A,OXCT2A,GAD2,ACSM5,HMGCS2,OXCT1,ACAT1,ACSM2,HMGCL |
| Alanine and aspartate metabolism | AGXT,DARS |
| GABA synthesis, release, reuptake and degradation | SLC6A1B,SNAP25A,SLC6A1A,SYT1A,SLC6A11,RAB3AA,STXBP1A,RAB3AB,SLC6A12,CPLX1 |
Protein Function
ABAT has several biochemical functions, for example, (S)-3-amino-2-methylpropionate transaminase activity,contributes_to 4-aminobutyrate transaminase activity,4-aminobutyrate transaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABAT itself. We selected most functions ABAT had, and list some proteins which have the same functions with ABAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | Scd1,YOD1,CYP2K17,ZFP207,EPT1,CYP1C2,TRAFD1,ATP9A,TSHZ1,ZFP2 |
| protein homodimerization activity | IMPA1,NPM1,CRTAM,DROSHA,AGR2,CRYM,CHMP1A,NADK2,BOKB,GSTA4 |
| iron-sulfur cluster binding | NFS1,FXN,AIFM4,NDUFS1,DPYDB,GLRX3,AOX3L1,CMAH,RSAD1,PROZA |
| pyridoxal phosphate binding | CBS,SRR,ETNPPL,HDC,LOC650128,CSAD,AGXT,PYGM,CCBL1,MARC2 |
Interacting Protein
ABAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABAT here. Most of them are supplied by our site. Hope this information will be useful for your research of ABAT.
CRK;ere_dna
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References
- Hallinen, TA; Soini, EJO; et al. Cost-utility of different treatment strategies after the failure of tumour necrosis factor inhibitor in rheumatoid arthritis in the Finnish setting. RHEUMATOLOGY 49:767-777(2010).
