AADAC
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Official Full Name
arylacetamide deacetylase (esterase) -
Overview
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which;catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens. -
Synonyms
AADAC;arylacetamide deacetylase (esterase);arylacetamide deacetylase;CES5A1;DAC;Aada;OTTHUMP00000216826;OTTHUMP00000216827
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- Insect Cells
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc&SUMO
- Flag
Involved Pathway
AADAC involved in several pathways and played different roles in them. We selected most pathways AADAC participated on our site, such as Biological oxidations,Metabolism,Phase 1 - Functionalization of compounds, which may be useful for your reference. Also, other proteins which involved in the same pathway with AADAC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phase 1 - Functionalization of compounds | CYP4T8,CYP2R1,CYP2C18,CYP2K19,CYP4F12,CYP2K6,CYP26A1,CYP2W1,CYP2K16,CYP2Y3 |
| Metabolism | C2orf56,DLAT,YAP1,ZDHHC21,NUDT5,ACOT6,PDP1,ACY3.1,NDUFAF6,PAICS |
| Biological oxidations | CYP4F11,SULT1ST6,SULT4A1,CYP2F1,CYP2S1,TPMT.2,SLC26A2,ADH6,CYP2AD6,CYP2J2 |
Protein Function
AADAC has several biochemical functions, for example, catalytic activity,deacetylase activity,lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AADAC itself. We selected most functions AADAC had, and list some proteins which have the same functions with AADAC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| deacetylase activity | HDAC2,HDAC1,MACROD1,NDST4,NDST1,MAPK1IP1L,NDST3,SIRT1,C6orf130,MACROD2 |
| triglyceride lipase activity | Cel,CES1,CEL.1,PNPLA3,LIPC,LIPF,PNLIPRP3,PNLIPRP2,LPL,CES1D |
| catalytic activity | GTF2F2A,UQCRC2B,HOGA1,SYN3,SPTLC2B,DIP2B,LANCL2,DBH,PPM1AB,ZRANB3 |
| serine hydrolase activity | ACHE,CELA2A |
| lipase activity | PNPLA7,LIPA,CELL,GOLT1A,LYPLA1,CES1C,Cel,GOLT1BB,ABHD2A,LIPM |
Interacting Protein
AADAC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AADAC here. Most of them are supplied by our site. Hope this information will be useful for your research of AADAC.
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References
- Ito, Y; Fukami, T; et al. An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver. DRUG METABOLISM AND DISPOSITION 42:2109-2116(2014).
- Shimizu, M; Fukami, T; et al. Screening of Specific Inhibitors for Human Carboxylesterases or Arylacetamide Deacetylase. DRUG METABOLISM AND DISPOSITION 42:1103-1109(2014).
