Nature: The Link between Inhibiting NLRP3 and Decreasing Alzheimer's

 According to a research led by Eicke Latz, MD from the University of Bonn in Germany, inhibiting a protein complex dubbed NLRP3 might slow the progression of Alzheimer's disease. People have known that the protein complex plays a role in inflammation, but it’s not clear if it contributes to the pathology of Alzheimer's. But experiments reported in Nature revealed one of the central roles of NLRP3.

 

The researchers crossed the mice with murine form of Alzheimer's and animals lacking elements of the NLRP3 complex. The resulting mice seemed to less commonly seen of the loss of spatial and object recognition memory when they aged. They also had lower levels of brain inflammation and the hallmark Alzheimer's disease protein—amyloid beta.

 

Other analysis also support that the NLRP3 connects to Alzheimer's. Taking together they assumed that therapies aimed at the so-called NLRP3 inflammasome "might effectively interfere with the progression of Alzheimer's disease."

 

Gene PTEN Absence and Aggressive Prostate Cancer

 

Some researchers did studies on mouse model and the result data found that precancerous prostate lesions with a cancer-suppressing gene lacking would rapidly evolved into aggressive prostate cancers when treated with androgen deprivation therapy (ADT).

 

Using a model of PTEN-driven prostatic intraepithelial neoplasia (PIN), investigators found that ADT maintained a stable pathologic status in the lesions. However, absence of PTEN led to development of aggressive prostate malignancies, regardless of whether medical or surgical ADT was used, as reported online in Cancer Discovery.

 

 

Article Link: Nature: The Link between Inhibiting NLRP3 and Decreasing Alzheimer's