ZYX
-
Official Full Name
zyxin -
Overview
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008] -
Synonyms
ZYX;zyxin;ESP-2;HED-2;zyxin-2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ZYX involved in several pathways and played different roles in them. We selected most pathways ZYX participated on our site, such as Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZYX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | GSK3B,RAC1,VCL,COL6A5,ITGA11A,FLT1,ITGB4,TESK2,BCL2A,THBS4A |
Protein Function
ZYX has several biochemical functions, for example, poly(A) RNA binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZYX itself. We selected most functions ZYX had, and list some proteins which have the same functions with ZYX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | IFIT2,CDK5R2,ZMAT3,NSUN5,SMNDC1,SLBP,NPM3,SRSF11,C14orf93,ADAR |
| zinc ion binding | KAT7B,RAG1,CAR7,PDLIM5B,APOBEC2A,ADAM8,CECR1,MSL2,QPCT,CCNB1IP1 |
| protein binding | CYBRD1,HMOX1,C11orf68,BCL2L15,PDPK1,SLC25A5,DEAF1,PGM1,KCNB1,SEPT2 |
Interacting Protein
ZYX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZYX here. Most of them are supplied by our site. Hope this information will be useful for your research of ZYX.
LATS1;VCAM1;E6;b2r9y1_human
Resources
Research Area
Focal Adhesion Proteins in Endothelial CellsFocal Adhesion Proteins in VSMC
Focal Adhesion Adaptor and Scaffold Proteins
Microfilament-associated Proteins
Actin Cytoskeleton and Stress Fiber Molecules
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References
- Wang, SL; Shi, XH; et al. Osteopontin (OPN) Is an Important Protein to Mediate Improvements in the Biocompatibility of C Ion-Implanted Silicone Rubber. PLOS ONE 9:-(2014).
- Felkl, M; Tomas, K; et al. Monitoring the Cytoskeletal EGF Response in Live Gastric Carcinoma Cells. PLOS ONE 7:-(2012).
